[ENDO-PORTER DELIVERY OF MORPHOLINO OLIGOS] Endo-Porter (PEG) [OT-EP-PEG-1], Endo-Porter (DMSO) [OT-EP-DMSO-1], Endo-Porter (Aqueous) [OT-EP-AQ-1]_Gene Tools - 코아사이언스

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Endo-Porter

DELIVERY OF MORPHOLINO OLIGOS

 

Cat.#                    Product                        Size

OT-EP-PEG-1        Endo-Porter (PEG)           1ml

OT-EP-DMSO-1    Endo-Porter (DMSO)        1ml

OT-EP-AQ-1        Endo-Porter (Aqueous)     1ml

Endo-Porter is a reagent for delivering Morpholino oligos, peptides or proteins into the cytosol of cultured cells. Endo-Porter is a peptide-based reagent which enters cells by endocytosis, works in the presence of 10% serum, and allows delivery of multiple oligos at a range of oligo concentrations. Delivery is least toxic when the process does not disrupt the plasma membrane. The mechanism of Endo-Porter delivery relies on Morpholinos and Endo-Porter being taken up from the media into the same endosome. Endo-Porter is an amphiphilic peptide with a sharp transition pH. It has a hydrophobic face which associates with cell membranes once added to culture medium. Morpholinos or other cargo molecules in the medium may be co-endocytosed with Endo-Porter. Natural acidification of the endosome protonates Endo-Porter and then, in its ionic form, Endo-Porter permeabilizes the endosome and releases the endosome contents into the cytosol (Summerton, 2005). Gene Tools provides Endo-Porter in three formulations, an aqueous PEG formulation, a DMSO formulation, and an aqueous formulation with mannitol. The aqueous PEG formulation contains 1mM Endo-Porter peptide and 10% polyethylene glycol 1500 mw in water. The aqueous PEG formulation combines the advantages of the older formulations and is our only recommended form of Endo-Porter, but we continue to offer the EndoPorter DMSO and older Endo-Porter Aqueous formulations to service legacy projects. 

 

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