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[Factor XIII] Human blood coagulation Factor XIII-A2 [T027]_ZEDIRA - 코아사이언스

코피디 2024. 6. 3. 11:28

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Human blood coagulation Factor XIII-A2

hFXIII, A subunit, recombinantly produced in insect cells

Cat.# T027 / Size: 200ug

 
Documents
 
Synonym
Recombinant Fibrin stabilizing factor, protein-glutamine-γ-glutamyltransferase

Molecular Weight
84 kDa (monomer); 168 kDa (homodimer)
 
Source
Recombinantly produced in insect cells
 
Purity
> 95% [by SDS-PAGE]
 
Appearance
White lyophilized solid.
 
Description
Recombinant human Factor XIII is a homodimer (A2) composed of two chains held together by non covalent bonds. After activation of the zymogen by Thrombin and Ca2+ to its active form (Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis.
 
Reagents
The recombinant human Factor XIII is lyophilized from 20 mM Tris-HCl pH 7.5, 150 mM NaCl, 1 mM EDTA, 1 mM DTT. Sample contains maltodextrin.
 
Reconstitution
Add the volume of water specified in the certificate of analysis under aliquotation to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. For short term storage keep cooled on ice.
 
Application
rhFXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue.
 
Storage
Storage for several months is possible at ≤ - 20°C.
Delivery is possible at ambient temperature.
Reference(s)
Böhm et al,. J. Med. Chem. 2014, 57:10355-65
Nikolajsen et al., J. Biol. Chem. 2014, 289:6526-34
Heil et al., Thromb. Res. 2013, 131, e214–e22
Schaertl et al., J. Biomol. Screen. 2010, 15:478-87
 
Note
INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.

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