[Newsletter] 2026년 4월 New Compounds_TargetMol - 코아사이언스

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TargetMol (Target molecule Corp.) 공식 수입/공급 업체 코아사이언스 입니다.

 

자세한 상품 정보 및 관련 문의는 전화 02-858-0328 또는 info@coresciences.co.kr로 문의주시기 바랍니다.

감사합니다!

 

Milvexian

Milvexian (BMS-986177/JNJ-70033093) is an orally bioavailable, small-molecule, reversible, and direct antagonist of Factor XIa (FXIa). It exhibits potent inhibitory activity across species, with Ki values of 0.11 nM for human, 0.38 nM for rabbit, and 0.64 nM for dog. By targeting FXIa, Milvexian selectively inhibits the intrinsic pathway of the coagulation cascade.

Research Areas: Cardiovascular Disease

Targets: Factor Xa

 

JD-13

JD-13 is a novel and potent Hsp90α inhibitor that binds to the ATP-binding pocket of Hsp90α (Kd = 1.60 μM), downregulates the Akt/β-catenin pathway, inhibits both wild-type and acyclovir-resistant HSV-1 infections, and alleviates skin lesions in guinea pigs caused by HSV-1 infection.

Research Areas: Infection

Targets: Hsp90α

 

CH5164840

CH5164840 is a potent, oral allosteric HSP90 inhibitor (IC50 = 4.1 nM). It suppresses tumor growth by degrading client proteins like HER2 and Akt in cancer research.

Research Areas: Cancer

Targets:HSP90

 

AC1115

AC1115 is a highly effective and selective antiviral compound targeting SARS-CoV-2 Mpro and the host lysosomal cysteine protease cathepsin L (CTSL), exhibiting potent antiviral activity.

Research Areas: Infection

Targets: SARS-CoV; Virus Protease; Cathepsin  

 

FJ9

FJ9 is an effective Wnt/β-catenin antagonist (Ki = 29 μM) that downregulates canonical Wnt signaling, inhibits HSC (hepatic stellate cell) activation, and reduces MeCP2 protein levels. FJ9 also disrupts the protein-protein interaction between Frz7 and the DVL PDZ domain, induces apoptosis in human cancer cell lines, and inhibits tumor growth in a mouse xenograft model.

Research Areas: Cancer

Targets: Na+/H+ Exchanger (NHE); Wnt; Apoptosis

 

M3258

M3258 is an immunoproteasome subunit LMP7 (β5i) inhibitor, with an IC50 of 3.6 nM for LMP7 and 3.4 nM at the cellular level. In a multiple myeloma xenograft model, M3258 exhibits significant antitumor activity. In multiple myeloma cells, M3258 significantly and persistently inhibits LMP7 activity and ubiquitinated protein turnover in tumor tissues, further inducing apoptosis.

Research Areas:Cancer

Targets: Proteasome; Apoptosis

 

Primordazine B

Primordazine B is a small molecule that selectively ablates Primordial Germ Cells (PGCs). It functions by specifically inhibiting a process known as Poly(A)-tail Independent Non-canonical Translation (PAINT), without interfering with typical Poly(A) tail-dependent translation (PAT).

Research Areas: Others

Targets: Others

 

 

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