[Magic Building Blocks Series 28] BCO building blocks_ChemScene - 코아사이언스

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Building Blocks & Bioactive Molecules 전문제조사 ChemScene 수입/공급 업체 코아사이언스 입니다.

 

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Introduction

Bicyclo[2.2.2]octane (BCO) is a saturated three-dimensional bridged bicyclic scaffold that has emerged as a promising bioisostere of benzene rings in medicinal chemistry. Its rigid, sp³-rich framework provides a compact, cage-like structure. This structurally stable framework delivers multiple desirable advantages in drug discovery: it significantly enhances metabolic stability by avoiding aromatic oxidation pathways, optimizes the balance between lipophilicity and aqueous solubility to improve druggability. Furthermore, it binds to the target without requiring significant conformational changes, thereby enhancing binding affinity and selectivity while reducing off-target risks. These features collectively make BCO a promising scaffold for optimizing ADME profiles and binding properties in lead optimization. So far, Chemscene has developed many BCO building blocks.

BCO building blocks

Brochures of ChemScene

 

Latest Publications Citing Use of ChemScene Products

Small 2407549, (2025).
Nat Protoc 20, 480-517 (2025).
Nat Commun 15, 10507 (2024).
Nat Commun 15, 7029 (2024).

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