[Newsletter] 2026년 2월 New Compounds_TargetMol - 코아사이언스

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Inhibitors & Agonists Compound Libraries Recombinant Proteins Virtual Screening

 

BAY-784

BAY-784 is a potent gonadotropin-releasing hormone receptor (GnRH-R) antagonist that exhibits strong inhibitory activity with IC50 values of 21 nM for human GnRH-R and 24 nM for rat GnRH-R, BAY-784 is widely applied in endocrine research to study GnRH signaling, reproductive hormone regulation, and therapeutic modulation of hormone-dependent physiological and pathological processes.

Research Areas: cancer
Targets: GnRH Receptor

 

SHP1705

SHP1705 is a potent and selective Cryptochrome 2 (CRY2) activator with circadian rhythm-modulating activity. It inhibits BMAL1-CLOCK transcriptional activity and prolongs survival in glioblastoma (GBM) mice established from glioblastoma stem cells (GSCs).

Research Areas: Canceer
Targets: CRY2 Activator

 

KP-1212

KP-1212 is a synthetic nucleoside analogue that exerts antiviral activity by inducing lethal mutagenesis of the viral genome, thereby increasing mutation rates beyond viral viability thresholds, and has been shown to inhibit HIV growth, making it a valuable research compound for studying antiviral mechanisms, viral replication fidelity, and mutation-driven therapeutic strategies.

Research Areas: Infection

Targets:HIV

 

Frovatriptan

Frovatriptan is a highly potent and cerebroselective agonist of the 5-HT1B/1D receptors, demonstrating the greatest receptor potency among clinically used triptan compounds, and it robustly activates serotonergic signaling pathways to modulate cranial vasoconstriction and trigeminal neurotransmission relevant to migraine pathophysiologyells.

Research Areas: Neurological Disease
Targets: 5-HT Receptor

 

GSK3494245

GSK3494245 is a Leishmania donovani inhibitor that suppresses trypsin-like activity catalyzed by the β5 subunit of L. donovani proteasome, applicable for visceral leishmaniasis (VL) studies..

Research Areas: Infection
Targets: Parasite;Proteasome  

 

Org GC 94

Org GC 94 is a psychoactive small-molecule compound belonging to the tetracyclic antidepressant (TeCA) therapeutic family, extensively characterized as a noradrenergic and specific serotonergic antidepressant (NaSSA) with clinically documented antidepressant, anxiolytic, hypnotic, antiemetic, orexigenic, and antihistamine pharmacological effects.

Research Areas:Neuroscience
Targets: H1 receptor

 

SR-29065

SR-29065 is a selective REV-ERBα agonist that inhibits BMAL1 transcription within the circadian transcription–translation feedback loop, and it has been applied to evaluate whether targeting both negative regulatory limbs of circadian control yields synergistic anti-tumor effects in glioblastoma models, supporting its broader use in autoimmune disorder and circadian rhythm research.

Research Areas: Inflammation/Immunology
Targets: REV-ERB  

 

 

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