[Magic Building Blocks Series 27] Cycloalkenyl boronate building blocks_ChemScene - 코아사이언스

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Introduction

Cycloalkenyl boronates are versatile building blocks in drug discovery. Their structure integrates three key features: a three-dimensional alicyclic ring, a readily functionalizable alkene, and a boronate group for Suzuki coupling. This design enables the efficient introduction of alicyclic moieties into drug candidates. Alicyclic rings enhance drug-like properties through increasing Fsp³ character, improving metabolic stability, and fine-tuning the balance between lipophilicity and aqueous solubility. Through Suzuki coupling, these cycloalkenyl boronates allow rapid modular assembly of complex, three-dimensional drug-like molecules, facilitating the exploration of structure-activity relationships and the optimization of lead compounds. So far, Chemscene has developed many cycloalkenyl boronate building blocks.

Cycloalkenyl boronate building blocks

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Latest Publications Citing Use of ChemScene Products

Small 2407549, (2025).
Nat Protoc 20, 480-517 (2025).
Nat Commun 15, 10507 (2024).
Nat Commun 15, 7029 (2024).

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