H10, biotinylated [PP-010]_Isca Biochemicals - 코아사이언스

 

H10, biotinylated

Cat.# PP-010 / Size: 1mg

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Structure:

Biotin-Gly-Gly-Gly-Ser-Gly-Met-Lys-Met-Gln-Val-Arg-Ile-Tyr-Leu-Val-OH

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Activity:

Biotinylated version of anterior gradient 2 (AGR2) binding peptide H10

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Description:

H10, biotinylated is the N-terminal biotinylated version of the anterior gradient 2 (AGR2) binding peptide H10 (MKMQVRIYLV) which was identified by mRNA display from a complex (>1011) library. AGR2 is a cancer-associated protein and increased levels of extracellular AGR2 (eAGR2) have been correlated with poor prognosis in cancer patients, making it a potential biomarker. H10 possesses high affinity binding to AGR2 with a KD of 6.4 nM, and has been used as the capture reagent in an AGR2 ELISA. H10 can also inhibit cancer cell migration in breast and prostate cancer cell lines.

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References:

Garri et al (2018) Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget 9(44) 27363 PMID: 29937991

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Technical Data

Structure	Biotin-Gly-Gly-Gly-Ser-Gly-Met-Lys-Met-Gln-Val-Arg-Ile-Tyr-Leu-Val-OH
Molecular Weight	1822.26
Formula	C79H132N22O21S3
Sequence	Biotin-GGGSGMKMQVRIYLV
Modifications	Biotinylated at N terminus

Solubility and Storage

Solubility	Soluble in water
Appearance	Freeze dried solid
Storage	Store dry, frozen and in the dark

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