티스토리 뷰

Phosoho-ErbB 2/EGFR (Tyr1248/Tyr1173) Rabbit Monoclonal Antibody

Cat. # AMRe01542 / Size: 50ul, 100ul, 500ul

 

Summary

Production Name
Phosoho-ErbB 2/EGFR (Tyr1248/Tyr1173) Rabbit Monoclonal Antibody
Description
Recombinant Rabbit Monoclonal antibody
Host
Rabbit
Application
WB
Reactivity
Human

 

Performance

Conjugation
Unconjugated
Modification
Phosphorylated
Isotype
IgG
Clonality
Monoclonal Antibody
Form
Liquid
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification
Affinity Purified

 

Immunogen

Gene Name
ERBB2
Alternative Names
ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340
Gene ID
2064
SwissProt ID
P04626

 

Application

Dilution Ratio
WB: 1/500-1/1000
Molecular Weight
Calculated MW: 138 kDa; Observed MW: 180 kDa

 

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

 

Research Area

Cancer

 

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