SHLP2 [CK-050]_Isca Biochemicals - 코아사이언스

SHLP2

Cat.# CK-050 / Size: 1mg

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Structure:

H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH

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Other Names:

Small humanin-like peptide 2

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Activity:

Binds to and activates CXCR7

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Description:

SHLP2 is one of six small humanin-like peptides (SHLP1 to 6) encoded by the 16S rRNA gene of the mitochondrial DNA genome, which is implicated in several biological processes such as aging and oxidative stress. SHLP2 induces β-Arrestin recruitment to CXCR7 with an EC50 of 0.9696 µM, and also binds directly to CXCR7, causing its internalization without affecting CXCR4. In vivo, administration of SHLP2 results in the suppression of food intake, activation of thermogenesis, and prevention of diet-induced obesity in mice. Activation of pro-opiomelanocortin (POMC) neurons by SHLP2 in the arcuate nucleus of the hypothalamus is involved in these processes. SHLP2 can also improve glucose tolerance and insulin sensitivity in vivo.

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References:

Cobb et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 4 796 PMID: 27070352

Nashine and Kenney (2020) Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD. Cells 9(5) 1102 PMID: 32365540

Kim et al (2023) Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nat Commun. 14(1) 4321 PMID: 37468558

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Technical Data

Structure	H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH
Molecular Weight	3015.58
Formula	C142H214N36O35S
Sequence	MGVKFFTLSTRFFPSVQRAVPLWTNS
Modifications	None

Solubility and Storage

Solubility	Soluble in water
Appearance	Freeze dried solid
Storage	Store dry, frozen and in the dark

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코아사이언스 coresciences Isca Biochemicals 한국 대리점 판매 peptide biochemicals 펩타이드 펩티드 7-Transmembrane receptors Antimicrobial agents Enzyme linked receptors Enzyme modulators Epitopes Ion channel modulators Nuclear receptor modulators Plant science Protein-protein interactions Transporters Peptides Antimicrobial peptides Biotin labelled peptides Cell penetrating peptides Fluorescent labelled peptides Myelin peptides Peptoids Small molecules Substrate peptides Adhesion molecules Antivirals Appetite regulation Cancer Cardiovascular Diabetes Endocrinology Epigenetics Immunology Metabolism Neuroscience Pain Regulated cell death Stem cells Ubiquitin-proteasome system