[Magic Building Blocks Series 12] 1,2,5-Oxadiazole building blocks_ChemScene - 코아사이언스

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Introduction

1,2,5-Oxadiazoles belong to a class of five-membered heterocycles that contain one oxygen atom and two nitrogen atoms, exhibiting interesting biological activity and thermodynamic properties. They have a strong inductive effect, comparable to that of trifluoromethyl or tetrazolyl groups. In contrast to the 1,2,4- or 1,3,4-oxadiazole isomers, the ability of 1,2,5-oxadiazoles to generate benzo-fused systems allows for the formation of a unique chemical space, enabling a balance between lipophilicity and polarity. In recent years, 1,2,5-oxadiazoles and their derivatives have been reported as good pharmacophores with anti-inflammatory, antibacterial, antihypertensive, and anticancer activities, etc. So far, Chemscene has developed many 1,2,5-oxadiazole building blocks.

1,2,5-Oxadiazole Building Blocks

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