Advancing Medicine with Recombinant Human Hyaluronidase PH20 [NATE-1923][CAS No. 37326-33-3]_Creative Enzymes - 코아사이언스

Recombinant Human Hyaluronidase PH20

Cat.# NATE-1923 / Size: inquire

Datasheet

 

Description

Recombinant Human Hyaluronidase (PH20) belongs to a family of enzymes that catalyze the degradation of hyaluronic acid and can degrade hyaluronic acid in the extracellular matrix and promote the diffusion of extracellular substances.

 

 

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Product Information

Source

CHO

Species

Human

Form

Liquid in sterile 20mM PB, 300mM NaCl, 0.1mM EDTA, 0.1mM CaCl2, pH6.8.

Enzyme Commission Number

EC 3.2.1.35

Activity

53,200 IU/mg

CAS No.

37326-33-3

Molecular Weight

The protein has a calculated MW of 51 kDa. The protein migrates as 60 kDa under reducing condition (SDS-PAGE) due to glycosylation.

Purity

> 95%

Unit Definition

One unit will cause a change in A600nm of 0.330 per minute at pH 5.7 at 37 ºC.

Storage

Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Endotoxin Level

< 0.1 EU per μg of the protein as determined by the LAL method.

 

Applications

Pharmaceutical Preparations

Hyaluronidase promotes the drug to break through the physical barrier of the extracellular matrix to achieve subcutaneous administration. Hyaluronidase is clinically used as a drug penetrant to promote drug absorption.

Tumor Microenvironment

Recombinant human hyaluronidase was introduced to target HA in the tumor microenvironment to treat tumors.

Gene Therapy

The use of hyaluronidase opens channels in the extracellular matrix, thereby enhancing the delivery of gene therapy.

 

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