Amyloid β-Protein (25-35) [4030205/H-1192][CAS no. 131602-53-4]_Bachem - 코아사이언스

 

Amyloid β-Protein (25-35)

=H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH

Product # 4030205 / Size: 1mg, 5mg

The biologically active domain of the amyloid β-protein for neurotrophic and neurotoxic effects is located in the β (25-35) sequence GSNKGAIIGLM, which is homologous to a region in peptides of the tachykinin family.

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Salt form: Trifluoroacetate

Molecular weight: 1060.28

Chemical Formula: C₄₅H₈₁N₁₃O₁₄S

Storage Temperature: < -15°C

One Letter code: GSNKGAIIGLM

Source: Synthetic

Old Product Number: H-1192

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Materials

Amyloid Beta Peptides & Alzheimer's Disease

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Literature

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity.

M.P.Mattson et al., J. Neurosci., 12, 376 (1992)

Effects of solvent on the structure of the Alzheimer amyloid-beta(25-35) peptide.

G.Wei and J.-E.Shea, Biophys. J., 91, 1638 (2006)

Folding and membrane insertion of amyloid-beta (25-35) peptide and its mutants: implications for aggregation and neurotoxicity.

H.-H.G.Tsai et al., Proteins, 78, 1909 (2010)

Beta-amyloid 25-35 peptide reduces the expression of glutamine transporter SAT1 in cultured cortical neurons.

D.Buntup et al., Neurochem. Res., 33, 248 (2008)

Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease.

C.J.Pike et al., Neuroscience, 63, 517 (1994)

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.

C.J.Pike et al., J. Neurochem., 64, 253 (1995)

Conformations and biological activities of amyloid beta peptide 25-35.

L.Millucci et al., Curr. Protein Pept. Sci., 11, 54 (2010)

Amyloid-beta(25-35) impairs memory and increases NO in the temporal cortex of rats.

I.D.Limon et al., Neurosci. Res., 63, 129 (2009)

Activation of macrophages by Alzheimer beta amyloid peptide.

A.Klegeris et al., Biochem. Biophys. Res. Commun., 199, 984 (1994)

Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy.

J.H.Ippel et al., Proc. Natl. Acad. Sci. USA, 99, 8648 (2002)

Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease.

C.J.Pike et al., Neuroscience, 63, 517 (1994)

 

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