Newsletter Synaptic Systems March 2024 - 코아사이언스

How can inflammatory processes be fine-tuned?

 

Two new antibodies against Arginase-1, a metabolic enzyme with a newly discovered role in inflammatory control

 

The immune system is the body's defense against pathological external and internal attacks. However, this powerful system must be strictly regulated, since an excessive inflammatory reaction could have serious and even lethal consequences.
Nitric oxide (NO) is a key signaling molecule involved in the control of various immune processes. Arginase-1 (Arg-1) competes with inducible nitric oxide synthase (iNOS) for arginine, and its activity can skew the immune response towards a more anti-inflammatory or "M2" phenotype (learn more about M1 and M2 phenotypes) in macrophages by limiting NO production via iNOS. Arg-1 is a protein primarily known for its role in the urea cycle within the liver where it catalyzes the hydrolysis of arginine to ornithine and urea.
We offer two new antibodies against Arg-1, one directed against the N-terminus and one directed against the C-terminus. Both show excellent performance in WB, IHC and FFPE (IHC-P) applications.

Indirect immunostaining of formalin fixed paraffin embedded mouse brain sections uninfected (A) or infected with T. gondii (B) using rabbit anti-mouse Arg-1 N-terminal antibody (cat. no. HS-500 013, dilution 1:4000, DAB). Nuclei have been counterstained with haematoxylin (blue).​

 

Rabbit polyclonal antibody against MARCO

 

The macrophage receptor with collagenous structure (MARCO) belongs to the class A scavenger receptor (SR-A) family. Scavenger receptors are pattern recognition receptors (PRRs) that are found most commonly on immune cells. MARCO is constitutively expressed by peritoneal macrophages and splenic marginal zone macrophages. Its expression can be induced in other macrophages, such as Kupffer cells or alveolar macrophages by bacterial infection or intravenous injection of LPS. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. After activation MARCO can also promote pro-inflammatory responses. Its expression on macrophages has been associated with tumor development and with Alzheimer's disease.
The new product we want to bring to your focus is a new mouse-specific rabbit polyclonal antibody against MARCO with superior results in WB, IHC and FFPE (IHC-P) applications.

Indirect immunostaining of a formalin fixed paraffin embedded mouse spleen section using Tyramide signal amplification with rabbit anti-MARCO (cat. no. HS-499 003, 1:2000, green) and rat anti-CD169 (cat. no. HS-495 017, dilution 1:500, red). Nuclei have been visualized by DAPI staining (blue).​

 

New rabbit polyclonal antibody against Taok2 beta

Thousand-and-one kinases (TAOKs) are members of the MAP kinase kinase kinase (MAP3K) family. One member of this family, Taok2 or TAO 2, is involved in the MAPK14/p38 MAPK stress-activated MAPK cascade, the SAPK/JNK and the Hippo signaling pathways. It can also influence cytoskeletal organization and stability, dendritic formation and the osmotic stress-MAPK8 pathway. Dysregulation of Taok2 has been observed in various pathological conditions such as cancer, Alzheimer's disease and autism. The new knock-out validated rabbit polyclonal antibody is directed against Taok2 beta and is highly suitable for WB and ICC applications.

Indirect immunostaining of formaldehyde fixed mouse hippocampus neurons with rabbit anti-Taok2 β antibody (cat. no. 395 103, dilution: 1:500, red).

 

New products we want to bring to your attention:

• new guinea pig recombinant monoclonal antibody against Calretinin, a good marker for cortical interneurons
• new biotinylated mouse monclonal antibody from HistoSure against the Nucleocapsid protein of the CoV-2 virus
• new human-specific rat monoclonal antibody from HistoSure against CD45, a widely used marker for leukocytes
• new chicken recombinant monoclonal antibody against parvalbumin, an excellent marker for a specific population of GABAergic interneurons
• new mouse monoclonal antibody against the HA-tag

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