[ADC Linker/Peptide Linker] Azide-PEG8-Val-Cit-PABC-SN-38 [BP-29793][CAS no. -]_BroadPharm - 코아사이언스

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Azide-PEG8-Val-Cit-PABC-SN-38

Cat.# BP-29793 / Size: 5mg, 10mg, 25mg, 50mg

Azide-PEG8-Val-Cit-PABC-SN-38 is a cleavable ADC linker with the SN-38 drug. SN-38 (7-Ethyl-10-hydroxycamptothecin) is a topoisomerase I inhibitor, and it inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is the active component of ADC drugs, IMMU-132. and also is the active metabolite of irinotecan. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

 

Formula: C63H87N11O21

MW: 1334.5

CAS:

Purity: 95%

 

Storage Condition: -20°C

Shipping: Ambient temperature

Availability: In Stock

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