Nintedanib Ethanesulfonate [B0084-434827][CAS no. 656247-18-6]_BOC Sciences - 코아사이언스

 

Nintedanib Ethanesulfonate

=Intedanib Ethanesulfonate

Cat.# B0084-434827 / Size: 500mg

Nintedanib esylate is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β.

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CAS no. 656247-18-6

Molecular Formula: C33H39N5O7S

Molecular Weight: 649.76

Related CAS: 656247-18-6 (esylate) 656247-17-5 (free base)

Appearance: Yellow solid powder

Synonyms: Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate; BIBF1120; BIBF 1120 BIBF-1120; Nintedanib esylate Nintedanib ethanesulfonate salt; Intedanib; Brand name OFEV Vargatef

IUPAC Name: ethanesulfonic acid;methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate

Application: the treatment of idiopathic pulmonary fibrosis

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Melting Point: >233°C (dec.)

InChI Key: MMMVNAGRWOJNMW-FJBFXRHMSA-N

InChI: 1S/C31H33N5O4.C2H6O3S/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38;1-2-6(3,4)5/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38);2H2,1H3,(H,3,4,5)/b29-28-;

Canonical SMILES:

​O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O

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