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CARDIOTOXIN (카디오톡신); CTX-1, Cytotoxin 1, Cardiotoxin gamma [L8102][CAS no. 56574-47-1]_Latoxan 수입/공급 전문 코아사이언스
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Latoxan 공식 수입/공급 업체 코아사이언스 입니다.
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CARDIOTOXIN
Cat.# L8102 / Size: 1mg, 5x1mg
Description
It is a protein kinase C specific inhibitor with an IC50 of 1-3 μM. It depolarizes cardiomyocytes. It has also lytic activity on other cells like red blood cells.
60-amino acid peptide with 4 disulfide bridges , from Naja pallida snake venom.
Biological activity
It interacts with sulfatides in the cell membrane. This induces pore formation and cell internalization responsible for cytotoxicity in cardiomyocytes. It has also an action on mitochondrial membrane which leads to swelling and fragmentation.
Product code | L8102 | Molecular weight | 6,800 Da |
Product name | CARDIOTOXIN | Physical form | |
CAS No. | 56574-47-1 | Melting point | |
RTECS | Solubility | Well in water and saline | |
UNIPROT | P01468 | Optical Activity | |
PubChem SID | |||
PubChem CID | |||
Purity | ≥ 95 % (isoelectrofocusing, HPLC); Phospholipase A2 activity < 2% | ||
Toxicity(LD50) | (LD100) mice (i.v.): 1.5-1.7 mg/kg | ||
Chemical Name | |||
Storage & Reconstitution Recommendations |
Stable in freeze-dried state In solution, keep at -20 °C |
||
Safety Recommendations | For research use only — not intended for food, diagnostic or therapeutic use |
Bibliographic References
- Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 32(8):2062-2067
- Fletcher et al., "Possible mechanisms of Action of cobra snake venom cardiotoxins and bee venom melittin." Toxicon 1993 31(6):669-695
- Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5): 2753-2758
- D'Albis et al., "Regeneration after cardiotoxin injury of innervated and denervated slow and fast muscles of mammals." Eur. J. Biochem. 1988 174:103-110
- Grognet et al., Molecular Immunology 1986 23(12):1329-1337
- Fryklund et al., Biochemistry 1975 14:2865
Links
PubMed |
Biomedical Citations From PubMed |
Toxicology Citations From PubMed |
UNIPROT |
* For Pharmaceutical and Medical Research Purposes Only !
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코아사이언스 coresciences LATOXAN S.A.S. Latoxan laboratory natural active ingredients France Korea 대리점 venom toxin plant small molecules 연구 목적 독소 식물 유래 저분자 물질 plant substances 카디오독소 심장독소
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