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CARDIOTOXIN 

=CTX-1, Cytotoxin 1, Cardiotoxin gamma

Cat.# L8102 / Size: 1mg, 5x1mg

Description

It is a protein kinase C specific inhibitor with an IC50 of 1-3 μM. It depolarizes cardiomyocytes. It has also lytic activity on other cells like red blood cells.


60-amino acid peptide with 4 disulfide bridges , from Naja pallida snake venom.

 

Biological activity

It interacts with sulfatides in the cell membrane. This induces pore formation and cell internalization responsible for cytotoxicity in cardiomyocytes. It has also an action on mitochondrial membrane which leads to swelling and fragmentation.

 

Product code L8102  Molecular weight 6,800 Da
Product name CARDIOTOXIN  Physical form  
CAS No. 56574-47-1 Melting point  
RTECS   Solubility Well in water and saline
UNIPROT P01468 Optical Activity  
PubChem SID      
PubChem CID      
Purity ≥ 95 % (isoelectrofocusing, HPLC); Phospholipase A2 activity < 2%    
Toxicity(LD50) (LD100) mice (i.v.): 1.5-1.7 mg/kg    
Chemical Name      
Storage & Reconstitution
Recommendations
Stable in freeze-dried state
In solution, keep at -20 °C

 
 
Safety Recommendations For research use only 
— not intended for food, diagnostic or therapeutic use

 

Bibliographic References

- Chiou et al., "Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition." Biochemistry 1993 32(8):2062-2067

- Fletcher et al., "Possible mechanisms of Action of cobra snake venom cardiotoxins and bee venom melittin." Toxicon 1993 31(6):669-695

- Raynor et al., "Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin." J. Biol. Chem. 1991 266(5): 2753-2758

- D'Albis et al., "Regeneration after cardiotoxin injury of innervated and denervated slow and fast muscles of mammals." Eur. J. Biochem. 1988 174:103-110

- Grognet et al., Molecular Immunology 1986 23(12):1329-1337

- Fryklund et al., Biochemistry 1975 14:2865

 

Links

 PubMed
 Biomedical Citations From PubMed
 Toxicology Citations From PubMed
 UNIPROT

* For Pharmaceutical and Medical Research Purposes Only !

 

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