[New Products] New Guinea pig polyclonal Aldolase C (Zebrin 2) antibody_Synaptic Systems - 코아사이언스

New Products

 

New Guinea pig polyclonal Aldolase C (Zebrin 2) antibody

 

The new antibody against Aldolase C, also referred to as Zebrin 2 or ALDOC, is specific for the "C" form of Aldolase and display excellent results in WB, ICC and IHC applications. The enzyme Aldolase C is a crucial player in ATP synthesis. In brain it is strongly expressed in the hippocampus, in Purkinje cell subpopulations and to a lesser level in astrocytes. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells (see also image below).

 

Indirect immunostaining of PFA fixed mouse cerebellum section with Guinea pig anti-Aldolase C (cat. no. 464 004, dilution 1 : 500, red) and rabbit anti-Calbindin D28k (cat. no. 214 008, dilution 1 : 500; green). Nuclei have been visualized by DAPI staining (blue).​

Knock-out validated Antibody against ApoE
 
Apolipoprotein E (ApoE) is one major apolipoprotein of several lipoprotein classes and mediates the cellular uptake of lipoproteins. High levels of ApoE protein are found in liver, brain, kidney or spleen. In the central nervous system ApoE is mainly expressed by astrocytes and smooth muscle cells around big vessels. Neurons and microglia increase ApoE expression after injury. A subtype of ApoE is implicated in Alzheimer's disease and cardiovascular disease.
This Guinea pig polyclonal antibody is KO-validated and is perfectly suited for WB, ICC and IHC applications.

 

Indirect immunostaining of PFA fixed mouse brain sections (Hippocampus - dentate gyrus) of wild type (WT) or ApoE knock-out (KO) mice with Guinea pig anti-ApoE (cat. no. 465 004, dilution 1 : 500; red). Nuclei have been visualized by DAPI staining (blue). Courtesy: Tissues were kindly provided by Prof. Hannelore Ehrenreich, MPI for Experimental Medicine Goettingen.

Microglia activation in focus

 

HistoSure's new mouse-specific rabbit polyclonal antibody targets CD86 and fits perfectly into our growing family of protein markers for microglial and macrophage activation, CD11b, CD11c, Chil3 and CD68. CD86, also known as B7.2, is expressed only at low levels on resting B cells, dendritic cells and macrophages; activation results in enhanced CD86 expression. In the CNS, CD86 upregulation is a marker of activated pro-inflammatory M1 microglia. This antibody has been thoroughly tested to achieve best results in WB, IHC and IHC-P applications. 

Indirect immunostaining of formalin fixed paraffin embedded non-perfused mouse brain sections of (A) naïve mouse brain and (B) Sars-CoV2 infected mouse brain with rabbit anti-CD86 (cat. no. HS-466 003; green) and rat anti-IBA1 (cat. no. HS-234 017; red). CD86 signal is detected in activated microglia (yellow) and in infiltrating immune cells (green). Nuclei have been visualized by DAPI staining (blue).

Furthermore, we would like to offer you additional new antibodies.  Three of them are produced recombinantly which eliminates lot-to-lot variancies but still allows you the possibility to choose from different host species.

• anti-c-Fos antibody monoclonal Guinea pig, recombinantly produced
• anti-GFAP antibody monoclonal Guinea pig, recombinantly produced 
• anti-Synaptotagmin 1 antibody monoclonal rabbit coupled to AbberiorStar 635P dye, recombinantly produced
• anti-VAChT antibody rat monoclonal (our first monoclonal VAChT antibody)
• anti-Piccolo antibody mouse monoclonal (our first monoclonal Piccolo antibody)

 

coresciences 코아사이언스 sysnaptic systems SYSY germany  antibody 항체 한국 신경생물학 neuroscience 면역 염색 IHC WB ICC 펩타이드 항원 펩티드 neurology