High‑Efficiency Conjugation for Early‑Stage Development & Screening_BaseClick - 코아사이언스

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Advancing ASGPR‑Targeted Delivery with Tri‑GalNAc Conjugation Formats

High‑Efficiency Hepatocyte Targeting

 

To give you more flexibility in conjugation and early‑stage testing, two Tri‑GalNAc formats are now offered in 1 mg:

1. Tri‑GalNAc‑DBCO (BCFA‑245‑1)
2. Tri‑GalNAc‑PEG3‑Azide (BCFA‑246‑1)

These formats enable rapid project initiation, screening rounds and small‑scale development, while maintaining baseclick’s high purity, structural integrity and reproducible click performance.

Why Tri‑GalNAc?

Tri‑GalNAc is a trivalent N‑acetylgalactosamine cluster that binds with high affinity to the asialoglycoprotein receptor (ASGPR), highly expressed on hepatocytes.

Its advantages are well‑characterized:

• High‑affinity ASGPR binding, ensuring selective hepatocyte uptake
• Fast receptor‑mediated internalization, improving intracellular access
• Stronger pharmacokinetic properties, enhancing oligo exposure in liver tissue
• Reliable ligand‑guided delivery, applicable to siRNA, ASO and mRNA modalities

Tri‑GalNAc has become a key element in targeted RNA therapeutics because it reliably enhances hepatic delivery without altering the underlying oligo sequence.

 

Tri‑GalNAc‑DBCO — 1 mg

For fast, copper‑free SPAAC conjugation

• High reactivity for rapid post‑synthetic labeling
• Ideal for post‑synthetic glycan installation on sensitive nucleic acids
• Perfect for sensitive RNA and ASO systems

Tri‑GalNAc‑PEG3‑Azide — 1 mg

Flexible Ligand for CuAAC/SPAAC workflows

• Hydrophilic PEG3 spacer increases solubility and reduces steric hindrance
• Compatible with modular linker exploration and conjugation optimization
• High compatibility with a broad range of oligo and nanoparticle systems
• Ideal for assay development, SAR screening, and pilot batches

Why Researchers trust baseclick’s Tri‑GalNAc Ligands

• In‑house manufacture ensures consistent quality and traceability
• Scalable production supporting R&D through preclinical stages
• High‑purity synthesis, resulting in minimal side products
• Excellent click performance, preserving oligo integrity
• Modular chemistry for smooth post‑synthetic installation

 

Our 1 mg formats are available immediately and ideal for Project kick‑off, Screening rounds, Small‑scale assays, Fast customer prototype development.

 

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