Find PEG Lipids for Your LNP Drug Delivery_Biopharma PEG Scientific Inc. - 코아사이언스

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PEG 및 PEG derivatives 합성 전문 제조사 Biopharma PEG Scientific Inc. 한국 대리점 코아사이언스 입니다.

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PEG lipids are essential for optimizing lipid nanoparticle (LNP) drug delivery, ensuring stability, enhanced circulation, and effective targeting. At Biopharma PEG, we provide high-quality PEG lipids to support your formulation needs.

 

The Role of PEG Lipids in LNPs

• Prevent Aggregation: Create a protective barrier to keep particles from clumping.
• Maintain Small Size: Help control LNP size for optimal performance.
• Extend Circulation Time: Prevent protein binding, allowing LNPs to stay in the bloodstream longer.
• Enhance Targeting: Support indirect targeting of therapies.
• Provide "Stealth" Properties: Help LNPs evade the body's clearance system, earning them the nickname “stealth agents.”

Scheme of the structure of the PEG molecule, Source: DOI:10.1007/s12026-024-09473-w

Explore Our GMP PEG Lipids

mPEG-DSPE

M.W,  1K, 2K, 3.4K, 4K, 5K, 10K, 20K

CAS No. 147867-65-0

A linear PEG phospholipid with saturated C18 stearoyl fatty acid, which contains hydrophilic and hydrophobic phospholipid PEG conjugates. It can be used in the formation of stealth liposomes or micelles, and can be used in targeted drug delivery and drug solubility enhancement.

 

DSPE-PEG-Mannose

M.W.  1K, 2K, 3.4K, 5K, 10K, 20K

DSPE-PEG-Mannose is a phospholipid for drug delivery systems, especially for mRNA vaccine delivery. It is an active target material, which can be used as an antitumor drug carrier and a liposome for targeted delivery.

 

DSPE-PEG-NH2

M.W.  1K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K

CAS No. 474922-26-4  

Used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.  

 

mPEG-N,N-Ditetradecylacetamide (ALC-0159)

M.W.  2K, 3.4K, 5K, 10K

CAS No. 1849616-42-7

Also known as ALC-0159, it is a PEG/lipid conjugate (i.e. PEGylated lipid).  According to public information,  it is one of the excipients of Pfizer's COVID-19 mRNA vaccine.  

 

Explore Other Lipids

Cholesterol (Plant-Derived)

CAS No. 57-88-5

Valuable in pharmaceuticals, especially in creating LNP drug delivery system. It helps stabilize these particles by maintaining membrane strength and integrity, making it useful for developing new drug delivery methods.

 

DSPE

CAS No. 1069-79-0

A phosphoethanolamine lipid used in liposome synthesis. It's crucial for creating stable, long-circulating liposomes, often modified with PEG for stealth properties, enhancing drug delivery in cancer treatments.

 

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코아사이언스 coresciences Biochempeg Scientific Inc.USA Korea distributor 한국 대리점 Biochempeg,  founded in 2013,  is a biotechnology-oriented company in Watertown, Massachusetts. We are dedicated to manufacturing and supplying high purity polyethylene glycol (PEG) derivatives and linkers, monodisperse PEG, ADC PEG linkers, Click Chemistry reagents,  PEGylation services and custom PEG derivative synthesis to clients worldwide. These PEG linkers have been widely used in bioconjugation, antibody-drug conjugates (ADCs) therapeutic, drug delivery and diagnostics field Biopharma PEG