KRH102140 [407964][CAS no. 864769-01-7]_MedKoo Biosciences - 코아사이언스

 

KRH102140

Cat.# 407964 / Size: inquire

Description: KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube formation in human umbilical vein endothelium cells. The results suggest that KRH102140 has potential therapeutic effects in alleviating various diseases associated with HIFs.

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CAS#: 864769-01-7

Chemical Formula: C25H24FNO

Exact Mass: 373.18

Molecular Weight: 373.471

Elemental Analysis: C, 80.40; H, 6.48; F, 5.09; N, 3.75; O, 4.28

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Synonym: KRH102140; KRH-102140; KRH 102140;

IUPAC/Chemical Name: N-(2-fluorobenzyl)-2-methyl-2-phenethyl-2H-chromen-6-amine

InChi Key: FOHRWJRCGKNFPV-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H24FNO/c1-25(15-13-19-7-3-2-4-8-19)16-14-20-17-22(11-12-24(20)28-25)27-18-21-9-5-6-10-23(21)26/h2-12,14,16-17,27H,13,15,18H2,1H3

SMILES Code: FC1=CC=CC=C1CNC2=CC=C(OC(CCC3=CC=CC=C3)(C)C=C4)C4=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

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