Dexamethasone (water-soluble) (수용성 덱사메타손) [HB6020][CAS no. 50-02-2]_Hello Bio - 코아사이언스

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Dexamethasone (water-soluble)

Cat.# HB6020 / Size: 100mg

 

Product Overview 

Name: Dexamethasone (water-soluble)

Short description: Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Water soluble and suitable for cell culture.

Biological description: Synthetic glucocorticoid which shows potent anti-inflammatory and immunospressant effects.

Induces differentiation of mesenchymal stem cells (hMSCs) into adipogenic, chondrogenic and osteogenic lineages.

Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.This is a water soluble compound composed of a dexamethasone – Cyclodextrin complex (Approx. 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin). Dexamethasone free base also available.

Biological action: Agonist

Purity: >98%

 

Properties 

• Chemical name
  (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• Molecular Weight
  6190.85
• Chemical structure

  

  
  
• CAS Number
  50-02-2
• PubChem identifier
  71308592
• SMILES
  CC1CC2C3CCC4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O
• InChi
  InChI=1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71
• InChiKey
  XEJNDGTUKUMQNG-ARJMFYCQSA-N
• MDL number
  MFCD00064136
• Appearance
  White to off-white solid
• Formulation
  Approximately 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin.

Storage & use 

Storage instructions: -20°C (protect from light)

 

*본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

 

References 

Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

Fan Z et al (2014) PLoS One 9(4) : e93264.

PubMedID: 24714627

Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.

PubMedID: 12695529

Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.

PubMedID: 20648425

*본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

코아사이언스 coresciences Hellobio Hello bio UK distributor 한국 대리점 G protein coupled receptors agonist antagonist cell process cell signaling ionotropic receptors cell imaging Enzyme inhibitors Enzyme activators Stem cell modulators Receptor ligands Signaling tools Epigenetic tools Ion channel modulatorsLifesciences GmbH 독일 한국 대한민국 cell selection & expansion exosome isolation protein production & assay cell isolation staining antigen specific T cell isolation & staining T cell stimulation & expansion