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연구용 시약

NOTEXIN (노텍신); Basic phospholipase A2 notexin, svPLA2 [L8104][CAS no. 37223-96-4]_Latoxan 수입/공급 전문 코아사이언스

코피디 2024. 6. 14. 09:48

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NOTEXIN

=Basic phospholipase A2 notexin, svPLA2

Cat.# L8104 / Size: 100ug, 5 x 100ug

Product ID L8104-100UG 
Name NOTEXIN 
Molecular formula Np Fraction: C591H878N164O175S16
Ns Fraction: C591H878N166O175S16
Description It is a toxic presynaptic phospholipase A2 (PLA2) with potent myotoxic activity.
Contains:
- Notexin Np (~60%)
- Notechis Ns (33%), a minor natural variant with K replaced by R in 16

119-amino acid protein with 7 disulfite bonds , from Notechis scutatus snake venom.
Biological activity Notexin exerts both presynaptic (blocks the release of acetylcholine) and myotoxic activities.

Chemical and Physical Properties

Product code L8104-100UG  Molecular weight 13574 Da
Product name NOTEXIN  Physical form  
CAS No. 37223-96-4 Melting point  
RTECS RD3800000 Solubility Well in water and saline
UNIPROT P00608;P00609 Optical Activity  
PubChem SID 134222164    
PubChem CID      
Purity > 93 % (HPLC)    
Toxicity(LD50) IVN-MUS LD50: 25 µg/kg    
Chemical Name      
Storage & Reconstitution
Recommandations		 Stable in freeze-dried state.
In solution, keep at -20 °C.		  
Savety Recommandations For research use only — not intended for food, diagnostic or therapeutic use
 

Bibliographic References

- Karlsson et al. Toxicon (1972). 10:405-413
- Mollier et al. Eur. J. Biochem. (1989). 185:263-270
- Halpert et al., J. Biol. Chem. (1975). 250:6990-6997
- Chwetzoff et al., FEBS Letters (1990). 161(2):226-230

 

Links

Product code L8104-100UG 
Product name NOTEXIN 
External Links  PubMed
 Biomedical Citations From PubMed
 Toxicology Citations From PubMed
 PubChem SID
 
 UNIPROT
 UNIPROT

* For Pharmaceutical and Medical Research Purposes Only !

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