Baricitinib Phosphate [326861][CAS no. 1187595-84-1 (phosphate)]_MedKoo Biosciences - 코아사이언스

Baricitinib Phosphate

Cat.# 326861 / Size: 50mg, 100mg, 200mg

 

 

Description: Baricitinib, also known as INCB-028050; INCB-28050; LY-3009104, is an oral highly selective JAK1 and JAK2 inhibitor for inflammatory and autoimmune diseases. There are four known JAK enzymes: JAK1, JAK2, JAK3 and TYK2. JAK-dependent cytokines have been implicated in the pathogenesis of a number of inflammatory and autoimmune diseases, suggesting that JAK inhibitors may be useful for the treatment of a broad range of inflammatory conditions. Baricitinib demonstrates approximately 100-fold greater potency of inhibition against JAK1 and JAK2 than JAK3 in kinase assays.

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CAS#: 1187595-84-1 (phosphate)

Chemical Formula: C16H20N7O6PS

Exact Mass: 0.00

Molecular Weight: 469.413

Elemental Analysis: C, 40.94; H, 4.29; N, 20.89; O, 20.45; P, 6.60; S, 6.83

 

Related CAS #: 1187594-09-7 (free base) 1187595-84-1 (phosphate)

Synonym: INCB-028050; INCB-28050; INCB 28050; INCB28050; LY-3009104; LY 3009104; LY3009104; Baricitinib Phosphate; Olumiant;

IUPAC/Chemical Name: (1-(Ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)ethanenitrile phosphate

InChi Key: FBPOWTFFUBBKBB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N7O2S.H3O4P/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14;1-5(2,3)4/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20);(H3,1,2,3,4)

SMILES Code: N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC)=O)C1.O=P(O)(O)O

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

 

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