[Gene Control Reagent] PIPA (Py-Im-Polyamide) - 코아사이언스

Alternative gene silencer other than siRNA or PNA

PIPA (Py-Im-Polyamide)

PIPA (Py-Im-Polyamide)는 비단백질 유래 아미노산으로 구성된 유전자 발현 조절 시약 입니다.

PIPA는 DNA 이중나선의 minor groove 내 특정 뉴클레오티드 서열과 높은 친화도와 특이성으로 결합 할 수 있습니다.

따라서 PIPA는 전사 인자들의 결합을 방해하여 유전자 발현을 억제하므로 유전자 조절제로 사용될 수 있습니다. 

  

PIPA (Py-Im-Polyamide) is a gene ｅxpression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).

PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene ｅxpression, thus PIPA can be used for gene-control.

Features 

• Alternative gene silencer other than siRNA or PNA
• Stable in cells or bodies because of nuclease resistance
• Specifically binds to the target double strand DNA
• Flexible Design against any gene
• No-toxicities have been found in animal experiments
• Form : Freeze dried powder
• No additives

Code	Structure (C-terminal amide)	Mol. Weight	Target Gene	Reference
HPTB01	Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp	1787.9	Human TGF-β1	1
HPTB02	Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp	1667.75	Human TGF-β1	1
HPTB03	Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp	1912	Human TGF-β1	1
HPTB04	Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp	1665.78	Rat TGF-β1	2
HPLH05	Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp	1911.01	Human LOX-1	3
HPLR06	Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp	1667.75	Rat LOX-1	4
HPCT07	Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp	1912	Human CTGF	5
HPTE08	Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp	1668.74	TMPRSS2-ERG	6*
HPTE09	Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp	1667.75	TMPRSS2-ERG	6*

* Published patent

References 

1. Igarashi, J. et. al., PLoS one. 2015,10, e0125295.
2. Matsuda, H. et. al., Kidney Int. 2011, 79, 46-56.
3. Kamei, T. et. al., J. Biomed. Biotechnol., 2012, 2102:715928.
4. Yao, E. H. et. al., Hypertension, 2008, 52, 86-92.
5. Wan, J. X.et. al., Biol. Pharm. Bull. 2011, 34, 1572-1577.
6. Obinata, D. et. al., Cancer Sci., 2014, 105, 1272-1278.
7. P. B. Dervan et. al., Nature (1998) 391 468-471
8. P. B. Dervan and R. W. Burli, Current Opinion in Chemical Biology 3 (1999) 688-693
9. P. B. Dervan, Bioorganic & Medicinal Chemistry 9 (2001) 2215-2235.

Ordering Information 

Product Name	Size	Cat.#	Storage
PIPA for Human TGF-β1	100μg	HPTB01	-20℃
<Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp>	1mg
PIPA for Human TGF-β1	100μg	HPTB02	-20℃
<Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp>	1mg
PIPA for Human TGF-β1	100μg	HPTB03	-20℃
<Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp>	1mg
PIPA for Rat TGF-β1	100μg	HPTB04	-20℃
<Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp>	1mg
PIPA for Human LOX-1	100μg	HPLH05	-20℃
<Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp>	1mg
PIPA for Rat LOX-1	100μg	HPLR06	-20℃
<Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp>	1mg
PIPA for Human CTGF	100μg	HPCT07	-20℃
<Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp>	1mg
PIPA for TMPRSS2-ERG	100μg	HPTE08	-20℃
<Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp>	1mg
PIPA for TMPRSS2-ERG	100μg	HPTE09	-20℃
<Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp>	1mg

NOTICE : FOR RESEARCH USE onLY. NOT FOR DIAGNOSTIC USE.

추천 상품

Mini Cell Strainer for 5 ml sampling tubes and 15 ml conical tubes [HT-AMS-12502, HT-AMS-14002, HT-AMS-17002]

BioMasher SP is a larger type of BioMasher II, disposable homogenizer. 

[일회용 호모게나이저,분쇄기,균질기_BioMasher] BioMasher SP_Disposable homogenizer for efficient and improved homogenization [893161, 893162, 893163, 893164]

[미니 셀 스트래이너/Single cell 분리] Mini Cell Strainer for 5 ml sampling tubes and 15 ml conical tubes [HT-AMS-12502, HT-AMS-14002, HT-AMS-17002] & Mini Cell Strainer II for 1.5 mL/2.0 mL tube and 5 ml sampling tubes [HT-AMS-04002, HT-AMS-04008]

[Cryotube Protective Pouch_동결튜브 보호/보관용 특수 필름] NIPRO CELL GATCH [87-449]

coresciences 코아사이언스 Funakoshi co., ltd Japan 일본 후나코시 Korea distributor 후나코시 한국대리점 siRNA PNA Peptide Nucleic Acid 유전자 발현 억제제 방해제 조절제 beta-alanine gamma-aminobutyric acid