Newsletter Synaptic Systems July 2023 - 코아사이언스

 

Don't forget about Arc

 

Activity-regulated cytoskeleton-associated protein (Arc) is a critical regulator of long-term synaptic plasticity at excitatory synapses, including long-term potentiation and long-term depression. It belongs like the transcription factor c-Fos to the family of the immediate-early genes (IEGs) that rapidly induced after patterned synaptic activity. Recent results have shown that it has also the ability to mediate intercellular transfer between neurons via extracellular vesicles (EVs).
We would like to introduce a new rat anti-Arc monoclonal antibody that can be used in collaboration with our recombinant c-Fos antibodies to study synaptic plasticity and neuronal activation.

 

Indirect immunostaining of a formaldehyde fixed mouse hippocampus section with rat anti-Arc antibody (cat. no. 156 017, dilution 1:500, red) and rabbit anti-c-Fos antibody (cat. no. 226 008, dilution 1:500, green). Nuclei have been visualized by DAPI staining (blue).​

T-bet (also known as Tbx21) belongs to the T-box subfamily Tbr1, and is an important transcription factor for the immune system, especially in immune response and cell fate determination. T-bet is a potent transactivator of the IFNγ gene and its expression correlates with IFNγ expression in Th1 cells, NK cells, and B cells. It has been discovered that T-bet plays also a role in experimental autoimmune encephalomyelitis (EAE), T-bet-deficient mice are resistant to EAE.
We want to bring your focus to our new mouse-specific (no signal in human samples) rat monoclonal anti-T-bet antibody which is ideally suited for FFPE applications (IHC-P). This product was developed from HistoSure, the branch from Synaptic Systems (SYSY) that is dedicated to immunology and cancer research.

 

Immunohistochemical staining of formalin fixed paraffin embedded mouse olfactory bulb with rat anti-T-bet (cat. no. HS-487 017, dilution 1:100, DAB). Nuclei have been visualized by haematoxylin staining (blue).

Further new products we want to to bring to your attention:

• rat monoclonal antibody against GluA2, an ionotropic glutamate receptor subunit
• affinity-purified polyclonal guinea pig antibody against Cre-recombinase
• biotinylated mouse monoclonal antibody against Aquaporin 4 (AQP4), a water-specific channel in the blood brain barrier

coresciences 코아사이언스 sysnaptic systems SYSY germany  antibody 항체 한국 신경생물학 neuroscience 면역 염색 IHC WB ICC 펩타이드 항원 펩티드 neurology