Cytokines in Immunology_Wuhan Fine Biological Technology - 코아사이언스

Cytokines in Immunology

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Types of Cytokines

Cytokines play an important role in intercellular signal transduction, which are synthesized and secreted by stimulation. They are involved in cellular activities by binding with relevant receptors, regulation of cell growth and differentiation, and immune response regulation. Cytokines include interleukins, interferons, tumour necrosis factors, colony-stimulating factors, and chemokines etc.

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FineTest Cytokine Products

FineTest offers a variety of cytokine Elisa kits featured in batch-to-batch consistency, excellent linearity range, high sensitivity and specificity, wide applications etc. High quality cytokine antibodies and proteins are also available with competitive price.

Interleukins

Interleukins are cytokines primarily found in leukocyte, which are generated by various cells and act on them. They are essential for regulating cellular processes(cell growth, differentiation and migration) and stimulating immune response.

CXCL8	IL7	IL36G	IL1B	IL37	IL4	IL20	IL36A
IL15	IL15RA	IL9	IL23	IL12	IL2	IL5	IL6
IL21	IL1A	IL10	IL11	IL17B	IL31	IL18	​
IL36B	IL22	IL16	IL17A	IL1RN	IL4R	IL20RA	​

Interferons

Interferons(IFN) are a group of signal proteins released and produced by host cells against a variety of existing viruses. Interferons are named after interfering with virus replication via preventing cells from viral infections. Interferons belong to cytokine proteins and are applied in intercellular communication. Pathogens are eliminated by triggering the protective defense of immune system.

IFNA1

IL1B

IFNA2

IFNB1

IFNG

Growth Factors

Growth factors also belong to proteins or steroidhormones. They are natural existing factors stimulating cell growth, differentiation, survival, inflammation and tissue repair. Growth factors are required by regulating different cellular processes. They can be secreted by adjacent cells, distant tissues and glands, and even tumor cells.

AREG	BDNF	FGF10	FGF8	HGF	IGF1	NOG	PGF
EREG	FGF1	FGF7	HBEGF	MET	NGF	PDGFB	​
FGF23	FGF4	GDNF	LIF	OSM	PDGFA	VEGFA	​
GDF6	GDF7	KITLG	NTF4	TGFB3	THPO	FGF21	​
IGFBP5	NRN1	NTF3	TGFB2	CYR61	EGF	GDF5	​
NRG1	PTN	TGFB1	CNTF	FGF19	FGF2	IGFBP3	​
PROK1	BMP2	BTC	FGF9	FGFR3	IGF2	NOV	​

Tumour Necrosis Factors

Tumour necrosis factors(TNF) are cytokines directly killing tumor cells. There is no obvious cytotoxicity for normal cells.

CD40LG	TNF	TNFRSF11B	TNFRSF13B	TNFSF15	TNFRSF1A	TNFRSF9
FAS	TNFRSF10B	TNFRSF12A	TNFSF13B	TNFRSF17	TNFSF9	TNFSF10
LTA	TNFRSF11A	TNFSF11	TNFRSF13C	TNFSF18	TNFRSF1B	​

Chemokines

Chemokines are cytokines with small molecular weight. They are mainly applied in recruiting leukocyte subsets under steady-state and pathological conditions and inducing chemotaxis of nearby reactive cells.

CCL1	CCL11	CCl12	CCL13	CCL14	CX3CL1	CCL3L1	CXCL3
CCL18	Ccl19	CCL2	CCL20	CCL21	PF4	CXCL1	XCL1
CCL24	CCL25	CCL26	CCL27	CCL28	CCL16	CXCL2	​
CCL5	CCl6	CCL7	CCL8	CCL15	CCL17	PPBP	​
CXCL11	CXCL12	CXCL13	CXCl14	Cxcl16	CCL22	CCL4	​
CXCL5	CXCL6	CXCL8	CXCL9	CCL3	CCL23	CXCL10	​

Colony-stimulating Factors

Colony-stimulating factors(CSFs) belong to glycoprotein and can bind with the receptor protein on the surface of hematopoietic stem cells. They can activate intracellular signaling pathway and promote the production of some hematocytes(e.g. leukocytes, neutrophil) to prevent infection.

CD40LG	CSF1	CSF2	TNF	TNFRSF10B	TNFRSF1B	TNFRSF9
KITLG	LTA	Thpo	TNFRSF17	TNFRSF1A	TSLP	GM-CSF
TNFRSF12A	TNFRSF13B	TNFRSF13C	TNFSF18	TNFSF9	FAS	TNFRSF11B
TNFSF11	TNFSF13B	TNFSF15	CSF3	EPO	TNFRSF11A	TNFSF10

Accquant® Elisa Kits for Cytokines

FineTest has developed some high sensitive Accquant® cytokine Elisa kits by using an optimized assay dilution. Accquant® Elisa kits not only reduce half sample requirement but also increase specific antibody-target protein binding which highly improve the kits’ sensitivity.

Advantages:

Half Sample Amount

10 Times Improved Sensitivity

Applications:

Valuable Samples: e.g. CSF, saliva

Immunoassay for healthy human samples

Catalog No	Product Name	Sensitivity	Range
AQ-H0201	Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit	0.28pg/ml	0.46-30pg/ml
AQ-H0374	Human HS-INS (High sensitive Insulin) Accquant® ELISA Kit	4.688pg/ml	7.813-500pg/ml
AQ-H0201-B	Human HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit	0.046pg/ml	0.078-5pg/ml
AQ-M0121-B	Mouse HS-IL-6(High sensitive Interleukin 6) Accquant® ELISA Kit	3.75pg/ml	6.25-400pg/ml
AQ-H0302-B	Human HS-TNF-α(High sensitive Tumor Necrosis Factor Alpha)Accquant® ELISA Kit	1.875pg/ml	3.1-200pg/ml
AQ-H0205-B	Human HS-IL-8 (High sensitive Interleukin 8) Accquant® ELISA Kit	0.46pg/ml	0.78-50pg/ml
AQ-H0164-B	Human HS-IFN-γ (High sensitive Interferon gamma) Accquant® ELISA Kit	1.41pg/ml	2.34-150pg/ml
AQ-H0176-B	Human HS-IL-12 p70 (High sensitive Interleukin 12 p70) Accquant® ELISA Kit	4.6pg/ml	7.8-500pg/ml
AQ-H0177-B	Human HS-IL-15 (High sensitive Interleukin 15) Accquant® ELISA Kit	0.875pg/ml	0.31-20pg/ml
AQ-H3267-B	Human HS-IL-17(High sensitive Interleukin 17) Accquant® ELISA Kit	3.75pg/ml	6.25-400pg/ml
AQ-H0198-B	Human HS-IL-33(High sensitive Interleukin 33) Accquant® ELISA Kit	1.875pg/ml	3.1-200pg/ml
AQ-H0011-B	Human HS-IL-18(High sensitive Interleukin 18) Accquant® ELISA Kit	0.983pg/ml	1.563-100pg/ml

Selected High IF Cited Cytokine Products

Many cytokine products are cited in international well-know journals. Some typical products are listed below.

• Article Title: Exosomal IFITM2 transmitted to DCs inhibits IFNα pathway activation and blocks anti‐HBV efficacy of exogenous IFNα
• IF: 17.425 Journal Title: Hepatology Detection Target: Human IFITM2
• Article Title: Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification
• IF: 16.016 Journal Title: Autophagy Detection Targets: Human IL-1β/Mouse IL-8
• Article Title: Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice
• IF: 10.717 Journal Title: Cell Death & Differentiation Detection Targets: Mouse TNF-α/IL-1β/IL-6

 

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