[감태/곤포 표준물질][Phenols] 6,6'-Bieckol [CFN80295][CAS no. 88095-81-2]_ChemFaces - 코아사이언스

6,6'-Bieckol

Cat.# CFN80295 / Size: 5mg

Cas No.: 88095-81-2

Purity: > 98%

C36H22O18 = 742.6

Physical Description: Powder

COA MSDS

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[ Source ]

The herbs of Ecklonia cava

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[ Biological Activity ]

6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells. 6,6'-Bieckol has liver protection against tert-butyl peroxide oxidative stress. 6,6'-Bieckol might inhibit TGF-β-induced EMT by down-regulating Snail1 and Twist1 and up-regulating E-cadherin in lung cancer cells. 6,6'-Bieckol is an ingredient in phlorotannin concentrate (PTC),PTC may exert antiallergic effects by immunomodulation of T cells and inactivation of inflammatory lymphocyte. 6,6'-bieckol, Against Photoaging by Inhibiting MMP-1, -3 and -9 Expression on UVB-induced HaCaT Keratinocytes 6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells 6,6'-bieckol protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells

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[Solvent]

Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

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[Storage]

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8°C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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[After receiving]

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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[ References ]

1. J Sci Food Agric . 2015 Jul;95(9):1830-1837. 6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells[Pubmed: 25142414]

2. Appl Biochem Biotechnol . 2011 Nov;165(5-6):1296-1307. Isolation of phlorotannins from Eisenia bicyclis and their hepatoprotective effect against oxidative stress induced by tert-butyl hyperoxide[Pubmed: 21892616]

3. Photochem Photobiol . 2022 Sep;98(5):1131-1139. A Phlorotanin, 6,6'-bieckol from Ecklonia cava, Against Photoaging by Inhibiting MMP-1, -3 and -9 Expression on UVB-induced HaCaT Keratinocytes[Pubmed: 34897721]

4. Mar Drugs . 2021 May 10;19(5):266. The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways[Pubmed: 34068815]

5. Immunopharmacol Immunotoxicol . 2016 Jun;38(3):244-252. 6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells[Pubmed: 27121731]

6. Fitoterapia . 2015 Oct;106:135-140. 6,6'-Bieckol protects insulinoma cells against high glucose-induced glucotoxicity by reducing oxidative stress and apoptosis[Pubmed: 26343533]

7. Appl Biochem Biotechnol . 2014 Sep;174(2):632-643. 6,6'-bieckol isolated from Ecklonia cava protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells[Pubmed: 25086922]

8. BMC Complement Altern Med . 2012 Oct 3;12:171. Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema[Pubmed: 23031211]

9. J Agric Food Chem . 2012 May 30;60(21):5340-5349. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells[Pubmed: 22587607]

10. Int Immunopharmacol . 2012 Mar;12(3):510-517. 6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE₂ production and inflammatory cytokine expression in macrophages: the inhibition of NFκB[Pubmed: 22289571]

11. Bioorg Med Chem . 2008 Sep 1;16(17):7921-7926. Anti-HIV-1 activity of phloroglucinol derivative, 6,6'-bieckol, from Ecklonia cava[Pubmed: 18693022]

12. J Agric Food Chem . 2008 Aug 27;56(16):7001-7009. Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical mediated oxidative systems[Pubmed: 18616277]

13. Appl Biochem Biotechnol . 2011 Nov;165(5-6):1296-1307. Isolation of phlorotannins from Eisenia bicyclis and their hepatoprotective effect against oxidative stress induced by tert-butyl hyperoxide[Pubmed: 21892616]

14. BMB Rep . 2010 Jan;43(1):62-68. Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava[Pubmed: 20132738]

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