HTI 286; SPA 110; Taltobulin [Axon1650][CAS no. 228266-40-8]_Axon Medchem - 코아사이언스

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HTI 286

=SPA 110; Taltobulin

Cat.# Axon 1650 / Size: 5mg, 2 x 5mg, 25mg

Tubulin polymerization inhibitor

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Chemical name

(S,E)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid

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CAS [228266-40-8]

MF C27H43N3O4

MW 473.65

Purity: 99%

Optical purity: Optically pure

Soluble in DMSO

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Description

Potent tubulin inhibitor; a synthetic hemiasterlin analogue, which is a potent inhibitor of cell growth with an additional advantage of circumventing the P-glycoprotein-mediated resistance

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References

F Loganzo et al. HTI-286, a Synthetic Analogue of the Tripeptide Hemiasterlin, Is a Potent Antimicrotubule Agent that Circumvents P-Glycoprotein-mediated Resistance in Vitro and in Vivo. Cancer Res. 2003, 63, 1838.

C Redaelli et al. Synthetic tubulin inhibitor HTI-286 and hepatocellular carcinoma: an in-vitro and and in-vivo study. J. Clin. Oncol. (Meeting Abstracts) 2005, 23(16S), 4201.

BA Hadaschik et al. Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int. J. Cancer. 2008, 122(10), 2368-2376.

Y Matsui et al. Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer. Mol. Cancer Ther. 2009, 8(8), 2402-2411.

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