(S)-3,5-DHPG [HB0045]_Hello Bio - 코아사이언스

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(S)-3,5-DHPG

Cat.# HB0045 / Size: 1mg, 5mg, 10mg

 

Product Overview 

• Name
  (S)-3,5-DHPG
• Short description
  Selective group I mGlu receptor agonist. Induces LTD.
• Biological description

  (S)-3,5-DHPG is a widely used selective group I mGlu receptor agonist (EC50 values are 2 and 6.6 µM at mGlu5 and mGlu1, 106 µM at mGlu3 and >1000 µM at mGlu2,4,7,8 receptors respectively).

  
  (S)-3,5-DHPG is the active enantiomer of DHPG. The racemic (R,S)-DHPG is also available.

  
  (S)-3,5-DHPG induces long term depression (LTD) (mGluR/DHPG-LTD). DHPG-LTD can temporarily be reversed by other mGluR antagonists such as (S)-MCPG.

  
  The CaMKII inhibitor KN-62 has also been shown to facilitate DHPG-LTD and (S)-3,5-DHPG-induced LTD is thought to involve rapid protein synthesis which can be antagonized by the protein synthesis inhibitor anisomycin.

  
  (S)-3,5-DHPG is active in vivo and shows a variety of biological actions.

• Biological action
  Agonist
• Purity
  >99%

 

Properties 

• Chemical name
  (S)-3,5-Dihydroxyphenylglycine
• Molecular Weight
  183.16
• Chemical structure

• Molecular Formula
  C8H9NO4
• CAS Number
  162870-29-3
• PubChem identifier
  443586
• SMILES
  C1=C(C=C(C=C1O)O)[C@@H](C(=O)O)N
• Source
  Synthetic
• InChi
  InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1
• InChiKey
  HOOWCUZPEFNHDT-ZETCQYMHSA-N
• MDL number
  MFCD11044457
• Appearance
  White solid

Storage & use 

Storage instructions: -20°C (desiccate)

Solubility overview: Soluble in water (50 mM) 

 

*본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

 

References 

Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice. Barton ME et al (2005) Neuropharmacology 48(6) : 779-87. PubMedID: 15829250

Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor. Hikichi H et al (2008) Eur J Pharmacol 586(1-3) : 212-6. PubMedID: 18378225

(S)-3,5-DHPG: a review. Wiśniewski K et al (2002) CNS Drug Rev 8(1) : 101-16. PubMedID: 12070529

Citations 

Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses. Tzounopoulos and Vogler(2018) bioRxiv doi : https://doi.org/10.1101/320671

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome. Costa et al (2018) Front Mol Neurosci. 11:353 : doi: 10.3389/fnmol.2018.00353 PubMedID: 30333723

Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines. Hlushchenko and Hotulainen(2019) Biol Chem : doi: 10.1515/hsz-2019-0110. PubMedID: 31280237

 

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