[도라지/길경 표준물질][Triterpenoids] Platycodin D (플라티코딘 D) [CFN98134][CAS no. 58479-68-8]_Chemfaces - 코아사이언스

 

Platycodin D

Cat.# CFN98134 / Size: 20mg    

 

 

Cas No.: 58479-68-8

Purity: > 98%

C57H92O28 = 1225.33

Physical Description: White powder

Manual    COA    MSDS 

 

[ Source ]

The root of Platycodon grandiflorum (도라지).

 

[ Biological Activity ]

Platycodon D shows antinociceptive, and anti-inflammatory activities, it can induce autophagy in NCI-H460 and A549 cells through inhibiting PI3K/Akt/mTOR signaling pathway and activating JNK and p38 MAPK signaling pathways. Platycodon D can inhibit migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Platycodin D is also a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen.

 

[Solvent]

DMSO, Pyridine, Methanol, Ethanol, etc.

 

[Storage]

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8°C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

 

[After receiving]

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

 

 

[References]

1. Evid Based Complement Alternat Med. 2014;2014:954508. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis.[Pubmed:24511322]

2. Int Immunopharmacol. 2015 Jun;26(2):338-48. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance.[Pubmed: 25887267]

3. Evid Based Complement Alternat Med. 2014;2014:478653. In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the h520 lung cancer cell.[Pubmed: 25477992]

4. J Ethnopharmacol. 2015 May 14. Effects of Gancao on pharmacokinetic profiles of platycodin D and deapio-platycodin D in Jiegeng.[Pubmed: 25980422]

5. Int Immunopharmacol. 2015 Jul;27(1):138-47.  Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro.[Pubmed: 25981110]

 

관련 상품

[Reference Standard_도라지/길경 표준물질] Platycodon grandiforus (Jacq.) A. DC. ingredients

[Reference standard_도라지/길경 표준물질] Platycodon ingredients; Desapioplatycodin D, Platycodin D, Platycodin D2

[후박나무/목련 표준물질][Lignans] Magnolol (마그놀롤); 5,5′-Diallyl-2,2′-biphenyldiol [CFN98872] [Cas No. 528-43-8]

[후박나무/목련 표준물질][Lignans] Honokiol (호노키올) [CFN99902][CAS no. 35354-74-6]

[Reference Standard_후박나무 표준물질] Magnolia officinalis Rehd et Wils. ingredients

 

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