CLK8 [Axon3224][CAS no. 898920-65-5]_Axon Medchem - 코아사이언스

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CLK8

Cat.# Axon 3224 / Size: 5mg, 2 x 5mg, 25mg

 

CLOCK/BMAL1 interaction inhibitor

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Chemical name: 2-[2-(8,8-Dimethyl-2-oxo-4-phenyl-9,10-dihydropyrano[2,3-f]chromen-5-yl)oxyacetamido]benzamide

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CAS [898920-65-5]

MF C29H26N2O6

MW 498.53

Purity: 98%

Soluble in DMSO

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Description

CLK8, a specific CLOCK-binding small molecule, inhibits the interaction between CLOCK and BMAL1 and interferes with nuclear translocation of CLOCK both in vivo and in vitro. CLK8 can be used to enhance circadian rhythm.

Keywords: CLK8 | supplier | CLOCK/BMAL1 inhibitor | CLK 8 | CLK-8 | CAS [898920-65-5] | DNA-RNA | CLOCK | Inhibitor | Transcription Factors | Circadian rhythm amplitude regulation | Brain and muscle Arnt-like protein-1 | BMAL1

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References

YU Doruk et al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295(11):3518-3531.

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