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연구용 시약

New Building Blocks for February 2022_ChemScene -코아사이언스

코피디 2022. 2. 24. 17:26

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Building Blocks & Bioactive Molecules 전문제조사 ChemScene 수입/공급 업체 코아사이언스 입니다.

 

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감사합니다!

Cyclopentane skeleton widely exists in many synthetic and natural bioactive molecules (prostaglandins, steroids, terpenoids, etc.)[1]. In order to minimize torsional strain, cyclopentane puckers to adopt an “envelope” conformation. Cyclopentanes on drugs may serve as either the core scaffold or an appendage to occupy a hydrophobic pocket of the target such as an enzyme or a receptor. Due to its unique properties, more and more building blocks containing cyclopentane are used in drug design[2-7].

 

A series of medicinal products containing Cyclopentane have been firmly incorporated in medical practice

[1] The Journal of Organic Chemistry (2015), 80, 24, 12212-12223.
[2] Journal of Medicinal Chemistry (2013), 56, 23, 9789-9801.
[3] Journal of Medicinal Chemistry (2019), 62, 5, 2265-2285.
[4] Journal of Medicinal Chemistry (2018), 61, 20, 9218-9228.
[5] Journal of Medicinal Chemistry (2015), 58, 3, 1281-1297.
[6] European Journal of Medicinal Chemistry (2021), 214,113194.
[7] European Journal of Medicinal Chemistry (2015), 93, 121-134.

 

 

코아사이언스 coresciences Chemscene Korea 한국 대리점 Korea distributor pharmaceutical ingredients natural compounds standards

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