[Webinar] Targeting RNA Structure as a Therapeutic Strategy (January 19th, 2022 14:00 EST)_BOC Sciences - 수입/공급 전문 코아사이언스

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Targeting RNA Structure as a Therapeutic Strategy

January 19th, 2022 14:00 EST | January 19th, 2022 20:00 CET

About Our Upcoming Webinar:

Across all domains of life and in viruses, RNA structures play critical roles in regulating gene expression. Although it has been known for decades that many RNAs such as riboswitches adopt multiple structures, traditional methods of characterizing RNA structures could either only determine the average structure (e.g., DMS-seq, SHAPE) or only be applied outside of cells (e.g., XRD, NMR). In order to characterize ensembles of alternative RNA structures (including SARS-CoV-2) inside living cells, Dr. Rouskin's lab recently developed the DREEM algorithm, which deconvolutes single-molecule chemical probing data (DMS-MaPseq) to identify alternative structures.

In this technical session, BOC Sciences has invited Dr. Rouskin from Harvard University to walk us through her previous and recent works related to the RNA genome that forms alternative conformations in cells. We will also learn about the therapeutic strategies for targeting RNA structures, as well as applying these novel techniques for future drug development.

 

Section Highlights
	Determine RNA Structure in Cells
	Quantify Alternative Conformations
	Target RNA Structure

Webinar Speaker

Silvia Rouskin, Ph.D.

Assistant Professor, Department of Microbiology

Harvard Medical School, Harvard University

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