[Newsletter] Explanation of Cytokines_ELK Biotechnology - 코아사이언스

1. The Past and present Life of interleukin

There is a group of protein molecules in the human body that are unknown but play a vital role in the immune system. They are interleukins (IL), Interleukins are a type of lymphokine produced by a variety of cells and interacting between leukocytes or immune cells. They are not only a key link in immune regulation, but also play an important role in hematopoiesis, anti-tumor and other aspects. In the 1970s, researchers first discovered interleukins in leukocytes and named them IL-1. The IL-1 series of cytokines have the function of regulating cell signal transduction and promoting cell proliferation. Since then, researchers have found that IL-1 can also induce fever and promote inflammatory responses. This study laid the foundation for subsequent interleukin research. As the research deepened, scientists have discovered many new interleukins. According to their functional and structural differences, interleukins are divided into different types and numbered in the form of IL-n (positive integers).

 

2. the main function of interleukin

The main functions of interleukins include but are not limited to the following aspects:

1) Immunomodulation: Interleukins play a core role in the regulation of immune responses. They can promote or inhibit the proliferation, differentiation and activation of immune cells, thereby regulating the intensity and direction of immune responses. For example, some interleukins (such as IL-2, IL-12) can stimulate the proliferation and activation of T cells and NK cells (natural killer cells) and enhance cellular immune responses; while other interleukins (such as IL-4, IL-10) may inhibit the activation of immune cells, helping to prevent excessive immune responses and the occurrence of autoimmune diseases.

2) Inflammatory response: Interleukins can attract and activate other immune cells (such as neutrophils and monocytes) to the site of inflammation, promoting the occurrence and development of local inflammatory responses. At the same time, interleukins can also regulate the production and release of inflammatory mediators, further exacerbating or alleviating inflammatory responses

3) Hematopoietic effect: Some interleukins have an important effect on the hematopoietic system. They can promote the proliferation and differentiation of hematopoietic stem cells, regulate the generation and development of erythroid, granulocyte, megakaryocyte and other cells, thereby maintaining normal blood components and proportions.

4) Participation in tumor immunity: Interleukins also play an important role in anti-tumor immunity. They can activate the anti-tumor activity of immune cells (such as NK cells and macrophages) and directly kill tumor cells; they can also promote the recognition and attack of tumor cells by immune cells and enhance the body's immune surveillance and clearance of tumors.

5) Other functions: In addition to the above main functions, interleukins are also involved in many other physiological and pathological processes, such as tissue repair, metabolic regulation, and neuro-endocrine-immune network regulation. It should be emphasized that the functions of interleukins are complex and diverse. Different interleukins differ in structure and function. They interact and regulate with each other to jointly maintain the homeostasis and balance of the immune system. At the same time, due to the important role of interleukins in immune response, they have also become important targets for the treatment of many diseases (such as autoimmune diseases, tumors, infectious diseases, etc.).

 

ELK Biotechnology products related to interleukin

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