Gö 6983; GO 6983; Goe 6983 [Axon2466][CAS no. 2621928-55-8]_Axon Medchem - 코아사이언스

안녕하세요!

Axon Medchem 공식 수입/공급 업체 코아사이언스 입니다.

 

자세한 상품 정보 및 관련 문의는 전화 02-858-0328 또는 info@coresciences.co.kr로 문의주시기 바랍니다.

감사합니다!

Gö 6983

=GO 6983; Goe 6983

Cat.# Axon2466 / Size: 5mg, 25mg, 2 x 5mg, 2 x 25mg

Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ

​

Chemical name

3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

​

CAS [133053-19-7]

MF C26H26N4O3

MW 442.51

Purity: 99%

Soluble in DMSO

​

Description

Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). Gö6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.

​KEYWORDS: GO 6983 | supplier | PKC inhibitor | GO6983 | Gö 6983 | Gö6983 | GO6983 | CAS [133053-19-7] | PKCμ | Inhibitor | MAPK | ERK | ischemia | reperfusion | IL-6 | proliferation | naïve | pluripotent | stem cells

​

References

M. Gschwendt et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.

I. Iankov et al. The effect of chemical blockade of PKC with Gö6976 and Gö6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells. Leuk Res. 2002 Apr;26(4):363-8.

K.C. Hwang et al. Chemicals that modulate stem cell differentiation. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7467-71.

O. Gafni et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6.

L.H. Young et al. Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev. 2005 Fall;23(3):255-72.

*본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

코아사이언스 coresciences​ Axon medchem 한국 대리점  Ligands small molecule inhibitors or modulators targeting more than 850 biological targets of cell signaling, gene transcription, apoptosis, cell cycle regulation, CNS stem cell research signaling oncology epigenetic research receptors Ion channels Biomarkers labeling reagent transcription factors ligand sets proteins screening library