[News Letter] Innovations in Enzyme Substrates and Drug Delivery_Biosynth - 코아사이언스

 

Enzyme Substrates Toolbox.
A Signalogenic Guide Part 1 - Chromogenic Substrates

 

 

We are thrilled to launch our "Enzyme Substrates Toolbox. A Signalogenic Guide Part 1 - Chromogenic Substrates".

This free guide, brought to you by Biosynth, your enzyme substrate experts, is a comprehensive guide that delves into the field of enzyme substrates, providing a scientific foundation for selection, exploration of chromogenic substrates and their applications and practical tips for selecting the perfect chromogenic substrate for your research.

This user-friendly ebook is packed with valuable information for researchers of all levels. Whether you are a seasoned scientist or just starting your enzyme journey, this ebook will equip you with the knowledge to understand chromogenic substrates and their science, confidently select the optimal substrate for your research, and gain practical tips for using enzyme substrates with initial experiment details.

 

Download eBook

 

Promising Tumor Growth Inhibitor through PEGylated APIT

 

Exciting news in cancer research! Our Biosynth colleagues in Berlin, Frank Leenders and Ralf Krähmer, together with a great team of scientists, published the results of their recent collaboration. The results show promising results in inhibiting tumor growth. PEGylation of Aplysia punctata ink toxin (APIT-PEG) increases its circulation time and stability in vivo.

The PEGylated recombinant production of APIT, an amino acid oxidase that depletes arginine and lysine, leads to a significant dose-dependent reduction in tumor growth over time, mediated by amino acid starvation of the tumor. The enzyme oxidizes the essential amino acids arginine and lysine to their corresponding deaminated alpha-keto acids, depriving auxotrophic cancer cells of these nutrients required for growth. PEGylation preserved APIT's enzyme characteristics while enhancing its in vivo stability after intravenous injection. 

Read this article and other recent publications from Biosynth on our publications page.

 

Read the Full Article

 

GalNac is Revolutionizing Drug Delivery

 

GalNAc clusters have emerged as a transformative tool for targeted drug delivery, enabling the effective transport of therapeutics to specific cell types. Extensive research has optimized GalNAc cluster design, with triantennary structures and defined linker lengths demonstrating potent targeting capabilities. GalNAc conjugation also improves the pharmacokinetic profile of attached drugs.

As a leading provider of carbohydrates and bioconjugation solutions, Biosynth offers an unparalleled selection of GalNAc clusters and derivatives. Our catalog includes diverse standard products, and we also provide custom synthesis services to help develop novel GalNAc-based delivery systems tailored to your needs. This includes modifying GalNAc clusters with various linkers, spacers, and conjugation strategies to fine-tune performance and pharmacokinetics.

 

Read Our White Paper

* 본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

 

코아사이언스 coresciences​ Biosynth Carbosynth limited UK Korea 한국 대리점