PEGANOLE (페가놀) [L6043][CAS no. 36101-54-9]_Latoxan - 코아사이언스

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PEGANOLE

=4,5-dihydropyrrolidino[2,1-b]quinazolin-5-ol

Cat.# L6043 / Size: 20mg, 100mg

 

Product ID	L6043
Name	PEGANOLE
Molecular formula	C11H12N2O
Description	It is a psychotomimetic agent on dogs and cats and an acetylcholinesterase inhibitor. ​ Alkaloid , derivative of Desoxypeganine from plants of the Zygophyllaceae family
Biological activity	Psychotomimetic effects:(unpublished results) dogs are specially sensitive to the psychotomimetic effects of Peganole. - 0.5 mg/kg (s.c.) on dogs (5-10 mg/kg on rats): disruption of conditioned reflex. - 1.0 mg/kg (i.v.): burst of motor activity and aggressiveness: usually, gentle dogs start growling, barking and biting various objects with fury during 15 to 20 minutes. After this period, dogs are depressed during 4 to 6 hours. - 3-5 mg/kg (i.v.) inhibit the synchronization of the main rhythm in the cortex and the reticular formation (activation reaction). - 31 mg/kg and 62 mg/kg (respectively 0.25 and half DL50) enhance respectively 2 and 2.5 times the length of sleep caused by chloral hydrate, although Peganole does not possesses any soporific effect by itself. Cholinergic effects:The main cholinergic effects of Peganole on mice (i.p., i.v. and s.c.) are as follow: - speeds up the breath rhythm; - causes tremor and clonic cramps; - enhances salivation and blood pressure. Peganole increases the effects of the cholinergic transmission in the CNS and at the neuromuscular junction. At 15, 30 and 50 mg/kg (i.p.), it increases respectively 1.5, 2 and 2.5 times the effects of Arecoline on tremor and 1.0, 1.8 and 3 times the effects of Nicotine. It inhibits both cholinesterases and monoamine oxydases.

Chemical and Physical Properties

Product code	L6043	Molecular weight	188.23 g/mol
Product name	PEGANOLE	Physical form	​
CAS No.	36101-54-9	Melting point	176-178 °C (decomp.)
RTECS	​	Solubility	Moderately soluble in chloroform, ethanol
UNIPROT	​	Optical Activity	​
PubChem SID	​
PubChem CID	3756584
Purity	> 95 %
Toxicity(LD50)	IVN-MUS LD50: 62 mg/kg IPR-MUS LD50: 130 mg/kg SCU-MUS LD50: 237 mg/kg
Chemical Name	4,5-dihydropyrrolidino[2,1-b]quinazolin-5-ol
Storage & Reconstitution Recommandations	Store at +4 °C, in dark place. ​
Savety Recommandations	For research use only — not intended for food, diagnostic or therapeutic use

​Bibliographic References

- Telejnetskaya et al., Chem. Nat. Comp. (1971). 6:849

- Telejnetskaya et al., Chem. Nat. Comp. (1989). 6:857

​

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