New Building Blocks for September 2023_ChemScene - 코아사이언스

안녕하세요!

Building Blocks & Bioactive Molecules 전문제조사 ChemScene 수입/공급 업체 코아사이언스 입니다.

 

자세한 상품 정보 및 관련 문의는 전화 02-858-0328 또는 info@coresciences.co.kr로 문의주시기 바랍니다.

감사합니다!

 

Protein arginine methyltransferase 5 (PRMT5) is a major type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of nuclear and cytoplasmic proteins[1]. PRMT5 plays a critical role in regulating biological processes including transcription, cell cycle progression, RNA splicing, and DNA repair. Currently, an increasing number of studies have identified the roles of PRMT5 as a tumor-promoting factor in several cancers. PRMT5 promotes the carcinogenicity of various solid tumors including colon, breast, prostate, lung, liver, bone, ovarian, gastric, and pancreatic cancers with poor clinical outcomes. In recent years, novel inhibitors of the PRMT5/MTA complex have been developed for the treatment of MTAP-deleted cancers. To date, no PRMT5 inhibitors have been approved by FDA and more than fourteen PRMT5 inhibitors have entered into clinical trials[2-10].

A series of building blocks will be used as molecular fragments in the design of PRMT5 inhibitors.

[1] Journal of Medicinal Chemistry (2022), 65, 3, 1749-1766.
[2] Journal of Medicinal Chemistry (2020), 63, 17, 9977-9989.
[3] Journal of Medicinal Chemistry (2021), 64, 7, 3911-3939.
[4] Journal of Medicinal Chemistry (2022), 65, 20, 13793-13812.
[5] Journal of Medicinal Chemistry (2023), 66, 13, 8407-8427.
[6] European Journal of Medicinal Chemistry (2019), 164, 317-333.
[7] European Journal of Medicinal Chemistry (2022), 244, 114842.
[8] Bioorganic & Medicinal Chemistry (2022), 71, 116947.
[9] ACS Medicinal Chemistry Letters (2018), 9, 7, 612-617.
[10] ACS Medicinal Chemistry Letters (2020), 11, 9, 1688-1693.

 

Cat. No. : CS-0498749	Cat. No. : CS-W008881	Cat. No.. : CS-W008618	Cat. No. : CS-0063913
CAS: 1572246-00-4	CAS: 454482-11-2	CAS: 160357-94-8	CAS: 135748-35-5

Cat. No. : CS-0374223	Cat. No. : CS-0159747	Cat. No. : CS-0043240	Cat. No. : CS-M3409
CAS: 2629317-93-5	CAS: 2629316-12-5	CAS: 1046831-98-4	CAS: 761446-44-0

Cat. No. : CS-0616151	Cat. No. : CS-0637392	Cat. No. : CS-W004741	Cat. No. : CS-0030585
CAS: 1350323-81-7	CAS: 1566524-62-6	CAS: 768-11-6	CAS: 1073354-91-2

Cat. No. : CS-B0456	Cat. No. : CS-W019601	Cat. No. : CS-0148057	Cat. No. : CS-0038699
CAS: 3680-69-1	CAS: 84955-31-7	CAS: 2086768-86-5	CAS: 115509-13-2

Cat. No. : CS-0042147	Cat. No. : CS-0183793	Cat. No. : CS-W005983	Cat. No. : CS-0102802
CAS: 871826-12-9	CAS: 182159-63-3	CAS: 37131-91-2	CAS: 16492-28-7

 

 

코아사이언스 coresciences Chemscene Korea 한국 대리점 Korea distributor pharmaceutical ingredients natural compounds standards