[브로콜리/양배추 표준물질] Sulforaphane (설포라판); Sulforafan; Sulforaphen; Detoxophane; 1-Isothiocyanato-4-(methylsulfinyl)-butane [CFN90203][Cas No. 4478-93-7]_ChemFaces - 코아사이언스

 

Sulforaphane

=Sulforafan; Sulforaphen; Detoxophane; 1-Isothiocyanato-4-(methylsulfinyl)-butane

Cat.# CFN90203 / Size: 5mg

*매우 불안정한 물질로 운송 중 순도 저하 가능 합니다.

 

Cas No.: 4478-93-7

Purity: > 98%

C6H9NOS2 = 177.29

Physical Description: Oil

COA    MSDS    

 

[ Source ]

The seeds of Brassica oleracea L. var. botrytis L.

 

[ Biological Activity ]

Sulforaphane is a cruciferous vegetable-derived isothiocyanate with promising antitumor, chemopreventive and therapeutic activities, it inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ. Sulforaphane may exert a significant neuroprotective effect on cholinergic deficit and cognitive impairment, it also has anti-inflammatory effect, at least ,in part,associated with interfering with the NF-κB pathway.

 

[ Solvent ]

Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

 

[Storage]

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8°C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be usable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

 

[After receiving]

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

 

[References]

1. J Biosci Bioeng. 2015 Jan;119(1):35-42. Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.[Pubmed:25070589]

2. J Nutr Biochem. 2014 Aug;25(8):824-33.  Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway.[Pubmed: 24880493]

3. Cancer Lett. 2014 Aug 28;351(1):41-9. Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK.[Pubmed: 24747121]

4. Int J Oncol. 2014 Oct;45(4):1497-506.  Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway.[Pubmed: 24993616]

5. Pharmacol Res. 2014 Jul;85:23-32.  Sulforaphane alleviates scopolamine-induced memory impairment in mice.[Pubmed: 24836869]

 

관련 상품: 글루코시놀레이트 (Glucosinolates)

(*아래에서 관심 상품을 클릭하시면 상세 정보를 열람할 수 있습니다)

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코아사이언스 coresciences wuhan chemfaces korea biochemical high quality phytochemicals reference standards analytical standard natural active ingredients products 표준품 기능성분 표준설포라판 항산화능 글루코시놀레이트 설포라페인 브로콜리 Brassica oleracea L. var. botrytis L. 꽃양배추 cauliflower  자주양배추 꽃양배추 cauliflower Sulforaphane Sulforafan 1-isothiocyanato-4-(methylsulfinyl)butane 4-isothiocyanatobutyl methyl sulfoxide Lepidium draba whitetop hoary cress 큰잎다닥냉이 꽃다지속 Brassica oleracea 브라시카 올레라케아 브로콜리 Broccoli Cardaria draba 애기냉이 4-Methylsulfinylbutyl isothiocyanate물질 지표성분 주성분 유효성분 순품