anti- CRK antibody [FNab01981]_Wuhan Fine Biological Technology - 코아사이언스

anti- CRK antibody

Cat.# FNab01981 / Size: 100ug

 

PRODUCT INFORMATION Product Name: anti- CRK antibody Catalogue No.: FNab01981 Size: 100µg Form: liquid Purification: Immunogen affinity purified Purity: ≥95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

IMMUNOGEN INFORMATION Immunogen: v-crk sarcoma virus CT10 oncogene homolog (avian) Observed MW: 37 kDa

APPLICATION Tested Application: ELISA, WB, IHC Recommended Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION UniProt ID: P46108

IMAGES Immunohistochemistry of paraffin-embedded human liver cancer using FNab01981 (CRK antibody) at dilution of 1:100 MCF7 cells were subjected to SDS PAGE followed by western blot with FNab01981 (CRK antibody) at dilution of 1:1000

 

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