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Paquinimod [319595][CAS no. 248282-01-1]_MedKoo Biosciences - 코아사이언스

코피디 2023. 3. 10. 17:55
 

Paquinimod

Cat.# 319595 / Size: 10mg, 25mg, 50mg, 100mg, 200mg

 

Description: Paquinimod, also known as ABR‑215757, is a S100A9 inhibitor preventing S100A9 binding to TLR-4. Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod treatment of collagenase-induced OA (CIOA) resulted in significantly reduced synovial thickening (57%), osteophyte size at the medial femur (66%) and cruciate ligaments (67%) and cartilage damage at the medial tibia (47%) and femur (75%; n=7, untreated n=6). Paquinimod reduces leukocyte recruitment during sterile inflammation. Paquinimod also reduced priming of proinflammatory effector CD4(+) T cells.

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CAS#: 248282-01-1

Chemical Formula: C21H22N2O3

Exact Mass: 350.163

Molecular Weight: 350.42

Elemental Analysis: C, 71.98; H, 6.33; N, 7.99; O, 13.70

 

Synonym: ABR‑215757; ABR 215757; ABR215757; Paquinimod.

IUPAC/Chemical Name: N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

InChi Key: DIKSYHCCYVYKRO-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22N2O3/c1-4-14-10-9-13-16-17(14)19(24)18(20(25)22(16)3)21(26)23(5-2)15-11-7-6-8-12-15/h6-13,24H,4-5H2,1-3H3

SMILES Code: O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2CC)N(CC)C3=CC=CC=C3

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

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