Anti Human Klotho Monoclonal Antibody (Clone No. KM2076) [KO603]_TransGenic/Funakoshi - 코아사이언스
Anti Human Klotho Monoclonal Antibody (Clone No. KM2076)
Cat.#: KO603
| Cat. No. | ：KO603 |
| Primary Source | ：HGNC:6344 |
| Type | ：Monoclonal Antibody |
| Target | ：klotho |
| Concentration | ：0.25 mg/mL |
| Contents（Volume） | ：50 μg（200 μL/vial) |
| Immunogen |
：Human Klotho 55-261a.a.
|
| Purification | ：ProteinG |
| Source | ：Serum Free Medium |
| Gene ID | ：9365 |
| Myeloma | ：P3U1 |
| Clone number | ：KM2076 |
| Isotype | ：IgG2a |
| Buffer | ：PBS [containing 2% Block Ace as a stabilizer,0.1% Proclin as a bacteriostat] |
| Cross Reactivity | ：Mouse, Rat |
| Label | ：Unlabeled |
| Storage | ：Store at - 20℃ long term, store at 4℃ short term. Avoid repeated freeze-thaw cycles. |
| Application | ：WB,IHC |
| ELISA | WB | IHC | ICC | IP | FCM | IF | Neutralization |
| Not tested | 1.0-5.0 | 2.0-10.0 | Not tested | Not tested | Not tested | Not tested | Not tested |
(µg/mL)
Description
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D By similarity. Essential factor for the specific interaction between FGF23 and FGFR1 By similarity.
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling By similarity.
References
- Kato Y, et al: Biochem Biophys Res Commun. 2000 Jan 19;267(2):597-602.*
- Tohyama O, et al: J Biol Chem. 2004 Mar 12;279(11):9777-84.
- Imura A, et al: FEBS Lett. 2004 May 7;565(1-3):143-7.*
- Imura A, et al: Science. 2007 Jun 15;316(5831):1615-8.*
- Brownstein CA, et al: Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3455-60.*
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