[Magic Building Blocks Series 17] Spirocyclic pyrrolidine building blocks_ChemScene - 코아사이언스

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Introduction

Spirocyclic pyrrolidine, characterized by its unique spiro ring structure, has gained significant attention in drug discovery. The spirocyclic framework creates a rigid, three-dimensional structure that enhances molecular stability and conformational specificity. This rigidity can improve the bioavailability and binding affinity of compounds by limiting flexibility, allowing for better interaction with biological targets. Additionally, the nitrogen atom in the pyrrolidine ring increases electron density, facilitating favorable polar interactions such as hydrogen bonding and electrostatic attraction with key residues on enzymes, receptors, or other targets. These interactions contribute to improved binding and higher selectivity for the target, enhancing the molecule's overall efficacy. So far, Chemscene has developed many spirocyclic pyrrolidine building blocks.

Spirocyclic pyrrolidine building blocks

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Latest Publications Citing Use of ChemScene Products

Small 2407549, (2025).
Nat Protoc 20, 480-517 (2025).
Nat Commun 15, 10507 (2024).
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