cPEPCK inhibitor [Axon1165][CAS no. 628279-07-2]_Axon Medchem - 코아사이언스

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cPEPCK inhibitor

Cat.# Axon 1165 / Size: 5mg, 25mg

• Certificate of Analysis
• Material Safety Data Sheet

cPEPCK inhibitor

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Chemical name

N-{4-[3-Butyl-1-(2-fluoro-benzyl)-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-acetamide

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CAS [628279-07-2]

MF C25H26FN5O3

MW 463.50

Purity: 98%

Soluble in DMSO

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Description

The first GTP-competitive inhibitor of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK or cPEPCK) with low submicromolar IC50 values.

KEYWORDS: cPEPCK inhibitor | supplier | cPEPCK inhibitor | CAS [628279-07-2] | Gluconeogenesis | PEPCK | GTP-competitive | human | cytosolic | phosphoenolpyruvate carboxykinase | glucose homeostasis | Type 2 | diabetes

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References

LH Foley et al. Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase. Bioorg. Med. Chem. Lett. 2003, 13(20), 3607-10.

LH Foley et al. X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines. Bioorg. Med. Chem. Lett. 2003, 13(21), 3871-4.

SL Pietranico et al. C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg. Med. Chem. Lett. 2007, 17(14), 3835-9.

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