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PEGANOLE (페가놀) [L6043][CAS no. 36101-54-9]_Latoxan - 코아사이언스
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2024. 4. 5. 15:15
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PEGANOLE
=4,5-dihydropyrrolidino[2,1-b]quinazolin-5-ol
Cat.# L6043 / Size: 20mg, 100mg
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Product ID
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L6043
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Name
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PEGANOLE
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Molecular formula
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C11H12N2O
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Description
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It is a psychotomimetic agent on dogs and cats and an acetylcholinesterase inhibitor.
Alkaloid , derivative of Desoxypeganine from plants of the Zygophyllaceae family
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Biological activity
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Psychotomimetic effects:(unpublished results) dogs are specially sensitive to the psychotomimetic effects of Peganole.
- 0.5 mg/kg (s.c.) on dogs (5-10 mg/kg on rats): disruption of conditioned reflex.
- 1.0 mg/kg (i.v.): burst of motor activity and aggressiveness: usually, gentle dogs start growling, barking and biting various objects with fury during 15 to 20 minutes. After this period, dogs are depressed during 4 to 6 hours.
- 3-5 mg/kg (i.v.) inhibit the synchronization of the main rhythm in the cortex and the reticular formation (activation reaction).
- 31 mg/kg and 62 mg/kg (respectively 0.25 and half DL50) enhance respectively 2 and 2.5 times the length of sleep caused by chloral hydrate, although Peganole does not possesses any soporific effect by itself.
Cholinergic effects:The main cholinergic effects of Peganole on mice (i.p., i.v. and s.c.) are as follow:
- speeds up the breath rhythm;
- causes tremor and clonic cramps;
- enhances salivation and blood pressure.
Peganole increases the effects of the cholinergic transmission in the CNS and at the neuromuscular junction. At 15, 30 and 50 mg/kg (i.p.), it increases respectively 1.5, 2 and 2.5 times the effects of Arecoline on tremor and 1.0, 1.8 and 3 times the effects of Nicotine. It inhibits both cholinesterases and monoamine oxydases.
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Chemical and Physical Properties
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Product code
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L6043
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Molecular weight
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188.23 g/mol
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Product name
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PEGANOLE
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Physical form
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CAS No.
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36101-54-9
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Melting point
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176-178 °C (decomp.)
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RTECS
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Solubility
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Moderately soluble in chloroform, ethanol
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UNIPROT
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Optical Activity
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PubChem SID
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PubChem CID
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3756584
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Purity
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> 95 %
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Toxicity(LD50)
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IVN-MUS LD50: 62 mg/kg
IPR-MUS LD50: 130 mg/kg
SCU-MUS LD50: 237 mg/kg
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Chemical Name
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4,5-dihydropyrrolidino[2,1-b]quinazolin-5-ol
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Storage & Reconstitution
Recommandations
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Store at +4 °C, in dark place.
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Savety Recommandations
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For research use only — not intended for food, diagnostic or therapeutic use
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Bibliographic References
- Telejnetskaya et al., Chem. Nat. Comp. (1971). 6:849
- Telejnetskaya et al., Chem. Nat. Comp. (1989). 6:857
Links
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