Find PEGs for Your LNP Drug Delivery_Biopharma PEG Scientific Inc. - 코아사이언스

안녕하세요!

PEG 및 PEG derivatives 합성 전문 제조사 Biopharma PEG Scientific Inc. 한국 대리점 코아사이언스 입니다.

관련 상품 견적 및 문의, 주문은 info@coresciences.co.kr로 연락주시기 바랍니다.

Biopharma PEG is dedicated to manufacturing PEG derivatives & PEG copolymers from lab to GMP commercial scale, which are widely used LNP drug delivery systems.

Lipid Nanoparticles (LNPs) are delivery systems commonly employed in the field of nucleic acid drugs.  LNPs mainly contain four components: a neutral phospholipid, cholesterol, a PEG-lipid, and an ionizable cationic lipid, among them, PEG lipids can have multiple effects on the properties of LNPs.

• Increase particle stability;
• Prolong the blood circulation time;

Conjugate specific ligands to the particle for targeted delivery.

Example PEGs for LNPs

mPEG-DSPE M.W,  1K, 2K, 3.4K, 4K, 5K, 10K, 20K CAS No. 147867-65-0

A linear PEG phospholipid with saturated C18 stearoyl fatty acid, which contains hydrophilic and hydrophobic phospholipid PEG conjugates. It can be used in the formation of stealth liposomes or micelles, and can be used in targeted drug delivery and drug solubility enhancement.

mPEG-N,N-Ditetradecylacetamide  M.W.  2K, 3.4K, 5K, 10K CAS No. 1849616-42-7

Also known as ALC-0159, it is a PEG/lipid conjugate (i.e. PEGylated lipid).  According to public information,  it is one of the excipients of Pfizer's COVID-19 mRNA vaccine.

DSPE-PEG-NH2 M.W.  1K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K CAS No. 474922-26-4

Used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

mPEG-DMG M.W.  1K, 2K, 3.4K, 5K, 10K CAS NO. 160743-62-4

mPEG-DMG is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. It has been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

DSPE-PEG-Mannose M.W.  1K, 2K, 3.4K, 5K, 10K, 20K

DSPE-PEG-Mannose is a phospholipid for drug delivery systems, especially for mRNA vaccine delivery. It is an active target material, which can be used as an antitumor drug carrier and a liposome for targeted delivery.

mPEG-AA M.W.  1K, 2K, 3.4K, 5K, 10K, 20K

mPEG-AA, also called mPEG-CM, carboxyl methyl,  is critical PEG material for PEGylated drug and LNP drug delivery system. There is a methylene (CH2) linkage between PEG and the COOH group.

* 본 상품은 오직 연구용으로만 사용 가능합니다. 인체 및 제품화에 사용하실 수 없습니다.

 

코아사이언스 coresciences Biochempeg Scientific Inc.USA Korea distributor 한국 대리점 Biochempeg,  founded in 2013,  is a biotechnology-oriented company in Watertown, Massachusetts. We are dedicated to manufacturing and supplying high purity polyethylene glycol (PEG) derivatives and linkers, monodisperse PEG, ADC PEG linkers, Click Chemistry reagents,  PEGylation services and custom PEG derivative synthesis to clients worldwide. These PEG linkers have been widely used in bioconjugation, antibody-drug conjugates (ADCs) therapeutic, drug delivery and diagnostics field Biopharma PEG