Newsletter Synaptic Systems June 2023 - 코아사이언스
New products
Watch our newest video about the beauty of the brain and the dangers it faces…
The brain is one of the most complex structures on our planet. In humans, it contains around 100 billion neurons, and many times more synapses. It is capable of amazing feats, but it is also one of the most energy consuming an vulnerable organs. Smallest changes in the microenvironment of the complex network of brain cells, can have dramatic effects on their fine-tuned functions.
Watch our new video that illustrates the complexcity of the brain, but also the dangers it faces. Learn, how our excellent antibodies from SYSY and HistoSure can help to elucidate the beauty, but also the neuropathological threats of this organ.
Click here for the video.
| Inhibition can be positive - superior antibodies for detecting inhibitory synapses |
The bulk of the brain’s neurons are excitatory, but the other side, the inhibitory neurons, are equally important. We offer several antibodies that can be used to analyze inhibitory neurons and now this group has 2 new members. First the recombinantly produced rabbit monoclonal antibody against the Glycine transporter 2 (GlyT2), also called SLC6A5. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6. It is mainly expressed in the spinal cord and brainstem where it transports Glycine back into the inhibitory neurons.
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Indirect immunostaining of a formaldehyde fixed mouse spinal cord section with rabbit anti-Glycine transporter2 antibody (cat. no. 272 008, dilution 1:500, red) and mouse anti-NeuN antibody (cat. no. 266 011, dilution 1:500, green). Nuclei have been visualized by DAPI staining (blue). |
The second antibody that we want to bring to your focus is a rabbit monoclonal anti-GAD1/GAD67 antibody. Glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to generate the major inhibitory neurotransmitter gamma-aminobutyric acid (GABA). In mammals, GAD exists in two isoforms with molecular weights of 67 and 65 kDa (GAD1/GAD67 and GAD2/GAD65). They are widely used markers for the GABAergic system, but despite their high homology, the regulation and expression of both forms is different.
| Indirect immunostaining of a formaldehyde fixed mouse brain section with rabbit anti-GAD1 antibody (cat. no. 198 208, dilution 1:500, red) and recombinant guinea pig anti-VGluT1 antibody (cat. no. 135 318, dilution 1:500, green). Nuclei have been visualized by DAPI staining (blue). |  |
Furthermore, we have added a new KO-validated rat monoclonal anti-LAMP3 antibody. LAMP3 (lysosome-associated membrane glycoprotein 3), also referred to as DC-LAMP (dendritic cell LAMP) or CD 208, is a member of the LAMP protein family. It is specifically expressed in lung type II pneumocytes and by activated human dendritic cells.
The following products are now available for you:
- A recombinantly produced monoclonal rabbit antibody against the Tyrosine hydroxylase.
- A recombinantly produced, KO-validated, monoclonal guinea pig anti-Syntaxin 1A antibody.
- Two mouse monoclonal antibodies against GluA, both fluorophore coupled (ATTO 488 and ATTO 565) and both are suitable for the surface staining of living cells.
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